TSNAX (Translin-associated protein X), also known as Translin-associated factor X, is a protein that forms a heteromeric complex with Translin (TSN). This complex, first identified in the 1990s, is evolutionarily conserved and implicated in nucleic acid metabolism, particularly RNA binding and transport. TSNAX lacks intrinsic enzymatic activity but stabilizes Translin, enabling their joint role in regulating mRNA trafficking, stability, and translation. The TSN-TSNAX complex is highly expressed in neuronal tissues and germ cells, suggesting roles in neurodevelopment, synaptic plasticity, and gametogenesis.
TSNAX antibodies are essential tools for studying the protein's expression, localization, and interaction networks. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore its biological functions. Research links TSNAX to neurological disorders (e.g., schizophrenia, Alzheimer’s) and cancer, where dysregulated RNA processing may contribute to pathogenesis. Antibodies targeting specific epitopes help dissect its involvement in cellular stress responses, DNA repair, or miRNA regulation. Commercial TSNAX antibodies are typically validated for specificity across human, mouse, and rat models, supporting translational studies. Ongoing research aims to clarify its mechanistic roles, making TSNAX antibodies critical for advancing molecular and therapeutic insights.