+ +

•  

   

     IHC-P analysis of skin tissue by POU2F3 antibody (P16003) IHC-P was performed using sections of the formalin-fixed paraffin-embedded skin tissue;Result: Squamous epithelial cells are positively stained at the nuclei.    

  
  

POU2F3. a member of the POU transcription factor family, plays a critical role in regulating gene expression and maintaining cellular identity. It is specifically expressed in certain epithelial and neuronal lineages, including Merkel cells and a subset of tuft cells in the gastrointestinal tract. Research has highlighted its importance in cancer biology, particularly in small cell lung cancer (SCLC), where POU2F3 is identified as a lineage-specific oncogenic driver in a distinct molecular subtype called SCLC-P. This subtype lacks neuroendocrine markers but relies on POU2F3 for survival and proliferation.

Antibodies targeting POU2F3 have become essential tools for studying its expression patterns, functional mechanisms, and therapeutic potential. These antibodies enable the detection of POU2F3 in tissue samples via immunohistochemistry (IHC) or immunoblotting, aiding in tumor classification and biomarker discovery. Recent studies also explore POU2F3 as a therapeutic target, with antibodies potentially guiding drug development for POU2F3-dependent cancers. However, challenges remain in understanding its regulatory networks and context-specific roles across tissues. Overall, POU2F3 antibodies are pivotal in advancing both basic research and clinical applications in oncology and developmental biology.