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     Western blot analysis using ZXDC mouse mAb against  mouse kidney tissue lysate    

  
  

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     Lane 1: Mouse kidney tissue lysate;  Lane 2: ZXDC immunoprecipitated from mouse kidney tissue by P15894;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15894 can immunoprecipitate ZXDC;    

  
  

ZXDC (Zinc Finger X-linked Duplicated Family Member C) is a protein encoded by the ZXDC gene, located on the X chromosome. It belongs to the zinc finger protein family, characterized by conserved zinc-binding domains that facilitate interactions with DNA, RNA, or other proteins. ZXDC is notably involved in transcriptional regulation and immune response modulation. Studies highlight its role in activating MHC class II genes, which are critical for antigen presentation and adaptive immunity. It interacts with the class II transactivator (CIITA), a key regulator of MHC-II expression, enhancing immune cell communication during infections or autoimmune conditions.

ZXDC also participates in chromatin remodeling and may influence cancer progression. Overexpression of ZXDC has been observed in certain malignancies, potentially linked to immune evasion mechanisms. Antibodies targeting ZXDC are valuable tools in research, enabling detection of protein expression, localization, and interaction partners via techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). These antibodies aid in elucidating ZXDC's functional pathways and its impact on immune regulation and oncogenesis. Further research is needed to explore its therapeutic potential in autoimmune diseases, infections, and cancer immunotherapy.