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FBLN5抗體,Rabbit Polyclonal FBLN5 Antibody
  • FBLN5抗體,Rabbit Polyclonal FBLN5 Antibody
  • FBLN5抗體,Rabbit Polyclonal FBLN5 Antibody
  • FBLN5抗體,Rabbit Polyclonal FBLN5 Antibody

FBLN5抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:FBLN5抗體英文名稱:Rabbit Polyclonal FBLN5 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5777 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): FBLN5
2025-05-21 FBLN5抗體 Rabbit Polyclonal FBLN5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5777 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesEVEC; UP50; ADCL2; ARMD3; DANCE; ARCL1A; FIBL-5; HNARMD
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human FBLN5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10851(FBLN5 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10851(FBLN5 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

1. **"Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo"**

- **Authors**: T. Nakamura et al.

- **摘要**: 研究通過(guò)生成FBLN5特異性抗體,驗(yàn)證其在調(diào)控彈性纖維組裝中的關(guān)鍵作用,并發(fā)現(xiàn)其缺失導(dǎo)致皮膚和血管彈性異常。

2. **"Fibulin-5 suppresses prostate cancer metastasis by inhibiting epithelial-mesenchymal transition"**

- **Authors**: M. Hirai et al.

- **摘要**: 利用抗FBLN5抗體進(jìn)行免疫組化分析,揭示其在抑制腫瘤轉(zhuǎn)移中的作用,并證明其通過(guò)調(diào)控EMT通路降低癌細(xì)胞侵襲性。

3. **"Fibulin-5 interacts with integrins to mediate endothelial cell adhesion and spreading"**

- **Authors**: H. Yanagisawa et al.

- **摘要**: 通過(guò)抗體阻斷實(shí)驗(yàn),證實(shí)FBLN5通過(guò)結(jié)合整合素調(diào)控內(nèi)皮細(xì)胞黏附,影響血管發(fā)育和修復(fù)過(guò)程。

4. **"Loss of fibulin-5 promotes aortic aneurysms via altered TGF-β signaling"**

- **Authors**: A.R. Albig et al.

- **摘要**: 使用FBLN5抗體檢測(cè)其在動(dòng)脈組織中的表達(dá),發(fā)現(xiàn)其缺失導(dǎo)致TGF-β信號(hào)失調(diào),進(jìn)而誘發(fā)動(dòng)脈瘤形成。

       

背景信息

The fibulin-5 protein (FBLN5), encoded by the *FBLN5* gene, is an extracellular matrix (ECM) glycoprotein critical for elastic fiber assembly and tissue integrity. It interacts with integrin receptors and ECM components like tropoelastin, facilitating cell adhesion, migration, and tissue remodeling. FBLN5 antibodies are essential tools for studying its roles in development, wound healing, and diseases.

Research applications include detecting FBLN5 expression via Western blot, immunohistochemistry (IHC), or immunofluorescence (IF) to explore its involvement in pathologies such as age-related macular degeneration, cardiovascular disorders, and cutaneous conditions like cutis laxa. Dysregulated FBLN5 is also linked to cancer progression, where it may act as a tumor suppressor or promoter depending on context, influencing metastasis and angiogenesis.

Commercial FBLN5 antibodies are typically monoclonal or polyclonal, raised against specific epitopes (e.g., human FBLN5 C-terminal regions). Validation ensures specificity in recognizing target isoforms across species. Studies using these antibodies have revealed FBLN5’s dual roles: maintaining elastin homeostasis in healthy tissues versus promoting inflammatory or fibrotic signaling when dysregulated. However, conflicting findings in cancer research highlight context-dependent functions, necessitating further investigation. Overall, FBLN5 antibodies remain vital for elucidating ECM biology and therapeutic targeting.

       
關(guān)鍵字: FBLN5抗體;FBLN5;FBLN5 Antibody;

公司簡(jiǎn)介

是一家科研、開(kāi)發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤(pán)

FBLN5抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥3104
VIP4年
上海博爾森生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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