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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10812(DISC1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P10812(DISC1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DISC1 (Disrupted in Schizophrenia 1) antibody is a key tool for studying the DISC1 protein, initially identified through genetic linkage studies in a Scottish family with a high prevalence of schizophrenia and mood disorders. Discovered in 2000. DISC1 gained attention due to a chromosomal translocation (1q42.1; 11q14.3) disrupting the gene, correlating with psychiatric phenotypes. The DISC1 protein plays critical roles in neurodevelopment, including neuronal migration, synaptic plasticity, and signaling pathways. It interacts with diverse molecular partners (e.g., NDEL1. PDE4B) to regulate processes like cAMP signaling and cytoskeletal dynamics.

DISC1 antibodies are widely used in research to detect protein expression, localization, and interactions in brain tissues or cell models. However, inconsistencies in antibody specificity (due to epitope variability, isoform diversity, or cross-reactivity) have led to challenges in replicating findings across studies. This has prompted calls for standardized validation protocols. Despite these issues, DISC1 remains a focal point in psychiatric and neurodevelopmental research, with antibodies aiding investigations into its role in mental illness pathophysiology. Recent efforts also explore its relevance in neurogenesis, mitochondrial function, and as a potential biomarker. Ongoing work aims to clarify DISC1's molecular mechanisms and therapeutic potential, emphasizing the need for high-quality, well-characterized antibodies to advance this field.