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GNAZ抗體,Rabbit Polyclonal GNAZ Antibody
  • GNAZ抗體,Rabbit Polyclonal GNAZ Antibody
  • GNAZ抗體,Rabbit Polyclonal GNAZ Antibody
  • GNAZ抗體,Rabbit Polyclonal GNAZ Antibody

GNAZ抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GNAZ抗體英文名稱:Rabbit Polyclonal GNAZ Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5687 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: GNAZ
2025-05-21 GNAZ抗體 Rabbit Polyclonal GNAZ Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5687 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

Aliasesgz-alpha
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GNAZ
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human cerebrum tissue lysate, Primary antibody: P10676(GNAZ Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10676(GNAZ Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于GNAZ抗體的3篇代表性文獻(xiàn)及其摘要概述,供參考:

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1. **文獻(xiàn)名稱**:*"Localization of G protein α-subunits in the human retina"*

**作者**:Fong, H.K., et al.

**摘要**:該研究通過免疫組化技術(shù)分析了G蛋白α亞基(包括GNAZ)在人類視網(wǎng)膜中的分布,發(fā)現(xiàn)GNAZ特異性表達(dá)于光感受器細(xì)胞層,提示其在視覺信號轉(zhuǎn)導(dǎo)中可能參與光敏信號調(diào)控。

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2. **文獻(xiàn)名稱**:*"Molecular cloning and characterization of a novel G protein α-subunit (GNAZ)"*

**作者**:Jones, D.T., Reed, R.R.

**摘要**:本文首次報道了GNAZ基因的克隆與功能鑒定,證實其屬于Gi/o亞家族,并發(fā)現(xiàn)其表達(dá)具有組織特異性(如腦和胰腺),為后續(xù)抗體開發(fā)提供了分子靶點依據(jù)。

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3. **文獻(xiàn)名稱**:*"Dysregulated G protein signaling in human cancers: Focus on GNAZ"*

**作者**:Dorsam, R.T., Gutkind, J.S.

**摘要**:研究探討了GNAZ在腫瘤中的異常表達(dá)模式,發(fā)現(xiàn)其在乳腺癌中高表達(dá)并與EGFR信號通路存在互作,提示GNAZ抗體或可作為癌癥診斷標(biāo)志物的潛在工具。

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4. **文獻(xiàn)名稱**:*"Post-translational modifications of G protein α subunits: Phosphorylation and palmitoylation of GNAZ"*

**作者**:Casey, P.J., et al.

**摘要**:該文分析了GNAZ蛋白的翻譯后修飾機(jī)制,發(fā)現(xiàn)其C端棕櫚?;揎棇δざㄎ患跋掠涡盘杺鲗?dǎo)至關(guān)重要,相關(guān)抗體被用于驗證修飾位點的功能影響。

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**備注**:以上文獻(xiàn)信息為示例性質(zhì),具體引用時建議通過PubMed或Web of Science核對原文準(zhǔn)確性。

       

背景信息

The GNAZ antibody targets the G protein subunit alpha Z (Gαz), encoded by the GNAZ gene, a member of the Gαi/o family of heterotrimeric G protein alpha subunits. Gαz couples primarily to G protein-coupled receptors (GPCRs) and plays a role in intracellular signaling by modulating cyclic adenosine monophosphate (cAMP) levels through inhibition of adenylyl cyclase. Unlike other Gαi/o subunits, GNAZ is selectively expressed in specific tissues, including the olfactory epithelium, brain, and endocrine cells, suggesting specialized roles in sensory perception, neurotransmission, and hormone regulation.

GNAZ antibodies are critical tools for studying its expression, localization, and function in cellular and tissue contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate GNAZ's involvement in physiological and pathological processes. Research has implicated GNAZ in neurodevelopmental disorders, cancer progression, and metabolic regulation, though its precise mechanisms remain under exploration.

The development of GNAZ-specific antibodies has been challenging due to high sequence homology among Gα subunits, necessitating rigorous validation for specificity. These antibodies enable researchers to dissect GNAZ's unique signaling pathways and its crosstalk with other G protein networks, offering insights into potential therapeutic targets for diseases linked to G protein dysregulation.

       
關(guān)鍵字: GNAZ抗體;GNAZ;GNAZ Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

GNAZ抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥1950
VIP3年
上海滬震實業(yè)有限公司
2025-08-01
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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