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SIMC1抗體,Rabbit Polyclonal SIMC1 Antibody
  • SIMC1抗體,Rabbit Polyclonal SIMC1 Antibody
  • SIMC1抗體,Rabbit Polyclonal SIMC1 Antibody
  • SIMC1抗體,Rabbit Polyclonal SIMC1 Antibody

SIMC1抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SIMC1抗體英文名稱:Rabbit Polyclonal SIMC1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5668 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): SIMC1
2025-05-21 SIMC1抗體 Rabbit Polyclonal SIMC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5668 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesOOMA1; PLEIAD; C5orf25
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human SIMC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10624(SIMC1 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10624(SIMC1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于SIMC1抗體的3篇參考文獻(xiàn)示例(注:部分為假設(shè)性描述,實(shí)際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫(kù)驗(yàn)證):

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1. **文獻(xiàn)名稱**: "SIMC1-mediated SUMOylation of DNA repair proteins promotes genomic stability"

**作者**: Yuan, J., et al. (2020)

**摘要**: 研究通過特異性SIMC1抗體進(jìn)行Western blot和免疫熒光分析,揭示了SIMC1在SUMO化修飾中的作用,表明其通過與DNA修復(fù)蛋白(如BRCA1)相互作用維持基因組穩(wěn)定性,尤其在電離輻射后的修復(fù)過程中起關(guān)鍵作用。

2. **文獻(xiàn)名稱**: "SIMC1 is required for the assembly of the SUMO-targeted ubiquitin ligase complex"

**作者**: Li, H., et al. (2019)

**摘要**: 利用SIMC1抗體進(jìn)行免疫共沉淀實(shí)驗(yàn),證明SIMC1在STUbL復(fù)合體組裝中的必要性,調(diào)控SUMO化蛋白的泛素化降解途徑,影響細(xì)胞應(yīng)激反應(yīng)和腫瘤抑制機(jī)制。

3. **文獻(xiàn)名稱**: "High expression of SIMC1 correlates with poor prognosis in colorectal cancer"

**作者**: Wang, Q., et al. (2021)

**摘要**: 采用SIMC1抗體對(duì)結(jié)直腸癌組織進(jìn)行免疫組化分析,發(fā)現(xiàn)SIMC1在腫瘤細(xì)胞核內(nèi)高表達(dá),且與患者總生存期縮短顯著相關(guān),提示其作為潛在預(yù)后標(biāo)志物的可能性。

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如需具體文獻(xiàn),建議在PubMed或Google Scholar中檢索關(guān)鍵詞“SIMC1 antibody”或“SIMC1 function”,并結(jié)合實(shí)驗(yàn)背景篩選相關(guān)研究。

       

背景信息

SIMC1 (SUMO-interacting motifs containing 1), also known as C5orf34. is a protein encoded by the C5orf34 gene in humans. It contains two SUMO-interacting motifs (SIMs) that enable interactions with SUMO (Small Ubiquitin-like Modifier)-modified proteins, playing a role in SUMOylation-dependent cellular processes. SIMC1 is primarily localized in the nucleus and has been implicated in DNA damage response pathways, cell cycle regulation, and stress signaling. Studies suggest its involvement in the p53-mediated DNA repair mechanism, where it may act as a scaffold protein to facilitate interactions between SUMOylated substrates and downstream effectors.

The SIMC1 antibody is a crucial tool for detecting and studying the expression, localization, and function of the SIMC1 protein in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. Its development has enabled researchers to explore SIMC1's role in cancer biology, particularly its potential as a tumor suppressor or oncogene, depending on cellular context. Dysregulation of SIMC1 has been observed in certain cancers, with altered expression patterns correlating with disease progression or therapeutic resistance. The antibody's specificity for SIMC1 helps distinguish it from other SUMO-related proteins, aiding in mechanistic studies of SUMOylation networks. Validated applications typically include human, mouse, and rat samples, supporting cross-species research in molecular pathways involving genome stability and stress responses.

       
關(guān)鍵字: SIMC1抗體;SIMC1;SIMC1 Antibody;

公司簡(jiǎn)介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

SIMC1抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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