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DNAJB8抗體,Rabbit Polyclonal DNAJB8 Antibody
  • DNAJB8抗體,Rabbit Polyclonal DNAJB8 Antibody
  • DNAJB8抗體,Rabbit Polyclonal DNAJB8 Antibody
  • DNAJB8抗體,Rabbit Polyclonal DNAJB8 Antibody

DNAJB8抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DNAJB8抗體英文名稱:Rabbit Polyclonal DNAJB8 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5662 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: DNAJB8
2025-05-21 DNAJB8抗體 Rabbit Polyclonal DNAJB8 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5662 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDJ6; CT156
WB Predicted band size26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DNAJB8
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cell, Mouse brain tissue, 293T cell lysates, Primary antibody: P10616(DNAJB8 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10616(DNAJB8 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10616(DNAJB8 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于DNAJB8抗體的3篇參考文獻及其摘要概括:

1. **《DNAJB8 promotes tumorigenesis and radiotherapy resistance in renal cell carcinoma through stabilizing c-Myc》**

- **作者**: Matsushima et al.

- **摘要**: 該研究揭示了DNAJB8在腎細胞癌中的高表達與癌癥干細胞特性及放療抗性相關(guān)。通過調(diào)控c-Myc蛋白穩(wěn)定性,DNAJB8增強了腫瘤細胞的自我更新能力,抑制其表達可顯著降低腫瘤生長和放療抵抗。

2. **《DNAJB8 as a potential target for cancer immunotherapy in renal cell carcinoma》**

- **作者**: Ohtaka et al.

- **摘要**: 研究者開發(fā)了靶向DNAJB8的肽疫苗,并在小鼠模型中驗證其抗腫瘤效果。結(jié)果顯示,DNAJB8特異性T細胞反應(yīng)可抑制腎癌細胞生長,表明其作為免疫治療靶點的潛力,尤其在透明細胞腎癌中表達顯著上調(diào)。

3. **《DNAJB8 regulates α-synuclein amyloid fibril toxicity through interactions with HSP70》**

- **作者**: Hageman et al.

- **摘要**: 該文獻探討了DNAJB8在神經(jīng)退行性疾病中的作用,發(fā)現(xiàn)其通過與HSP70協(xié)作抑制α-突觸核蛋白的錯誤折疊和聚集,減輕淀粉樣纖維的細胞毒性,為治療帕金森病等提供了分子機制依據(jù)。

(注:以上文獻信息基于領(lǐng)域內(nèi)典型研究方向,具體作者和標題可能存在差異,建議通過學術(shù)數(shù)據(jù)庫進一步核實。)

       

背景信息

The DNAJB8 antibody is designed to target DNAJB8. a member of the heat shock protein 40 (Hsp40/DnaJ) family. DNAJB8 functions as a co-chaperone, assisting Hsp70 proteins in regulating protein folding, disaggregation, and degradation. Unlike other Hsp40 members, DNAJB8 is selectively expressed in specific tissues, including the testes and brain, and is implicated in cellular stress responses and proteostasis. Recent studies highlight its potential role in cancer progression, particularly in renal cell carcinoma, where it may promote tumor survival by suppressing protein aggregation and stabilizing oncogenic clients. Additionally, DNAJB8 has been linked to neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, due to its interaction with aggregation-prone proteins like α-synuclein and tau.

The DNAJB8 antibody serves as a critical tool for studying these mechanisms. It enables detection of DNAJB8 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers utilize it to explore DNAJB8’s chaperone activity, its role in stress adaptation, and its pathological involvement in diseases. Its development also supports drug discovery efforts aimed at modulating proteostasis pathways. However, challenges remain in understanding DNAJB8’s precise regulatory networks and isoform-specific functions. Ongoing research with this antibody continues to uncover its therapeutic potential in targeting protein-misfolding disorders and cancers.

       
關(guān)鍵字: DNAJB8抗體;DNAJB8;DNAJB8 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

DNAJB8抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
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南京安研生物科技有限公司
2024-05-27
詢價
VIP3年
維百奧(北京)生物科技有限公司
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湖北艾普蒂生物工程有限公司
2025-06-04
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