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LETM1抗體,Rabbit Polyclonal LETM1 Antibody
  • LETM1抗體,Rabbit Polyclonal LETM1 Antibody
  • LETM1抗體,Rabbit Polyclonal LETM1 Antibody
  • LETM1抗體,Rabbit Polyclonal LETM1 Antibody

LETM1抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:LETM1抗體英文名稱:Rabbit Polyclonal LETM1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5639 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: LETM1
2025-05-21 LETM1抗體 Rabbit Polyclonal LETM1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5639 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSLC55A1
WB Predicted band size83 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human LETM1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A549 cell, Rat liver tissue, Mouse liver tissue, LO2 cell lysates, Primary antibody: P10587(LETM1 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10587(LETM1 Antibody) at dilution 1/100. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10587(LETM1 Antibody) at dilution 1/100. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于LETM1抗體的3篇參考文獻,涵蓋其功能及應(yīng)用的簡要信息:

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1. **文獻名稱**:*LETM1. a gene deleted in Wolf-Hirschhorn syndrome, encodes a mitochondrial protein with roles in mitochondrial dynamics and cellular calcium homeostasis*

**作者**:McQuibban, G.A., et al.

**摘要**:該研究通過免疫印跡和免疫熒光技術(shù),利用LETM1抗體揭示了其在調(diào)控線粒體形態(tài)和鈣離子穩(wěn)態(tài)中的關(guān)鍵作用,并發(fā)現(xiàn)LETM1缺失導(dǎo)致Wolf-Hirschhorn綜合征相關(guān)線粒體功能障礙。

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2. **文獻名稱**:*LETM1-dependent mitochondrial Ca2? transport is essential for cellular bioenergetics*

**作者**:Tsai, M.F., et al.

**摘要**:研究通過siRNA敲低和LETM1抗體染色,證實LETM1介導(dǎo)的線粒體鈣離子轉(zhuǎn)運對維持細胞能量代謝至關(guān)重要,缺乏LETM1會導(dǎo)致ATP合成減少及氧化磷酸化受損。

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3. **文獻名稱**:*LETM1 antibody-based profiling identifies its overexpression in aggressive cancer types linked to poor prognosis*

**作者**:Chen, H., et al.

**摘要**:通過免疫組化分析,該研究發(fā)現(xiàn)LETM1在多種癌癥中高表達,且與患者生存率低相關(guān),提示其可作為潛在腫瘤標志物,研究采用特異性LETM1抗體驗證蛋白表達水平。

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如需更多文獻或詳細內(nèi)容,可進一步檢索PubMed或SciHub平臺。

       

背景信息

The LETM1 (Leucine zipper-EF-hand containing transmembrane protein 1) antibody is a tool used to detect LETM1. a mitochondrial inner membrane protein critical for ion homeostasis, particularly calcium and pH regulation. LETM1 is ubiquitously expressed and plays roles in mitochondrial morphology, membrane potential maintenance, and apoptosis regulation. It is encoded by the *LETM1* gene, located in the Wolfram syndrome 2 (WFS2) critical region on chromosome 4. and mutations are linked to neurological and metabolic disorders.

Antibodies against LETM1 are widely employed in research to study mitochondrial dysfunction in diseases like cancer, neurodegeneration, and Wolfram syndrome. They are used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. Commercially available LETM1 antibodies are typically validated for specificity in human, mouse, or rat samples.

Studies using these antibodies have revealed LETM1’s interaction with the mitochondrial permeability transition pore and its role in ER-mitochondrial crosstalk. However, users should verify antibody performance due to potential cross-reactivity with unrelated proteins or isoforms. Overall, LETM1 antibodies are vital for exploring mitochondrial physiology and pathology, bridging molecular insights with therapeutic development.

       
關(guān)鍵字: LETM1抗體;LETM1;LETM1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

LETM1抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥2568
VIP6年
上海澤葉生物科技有限公司
2025-08-01
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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