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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human stomach tissue lysate, Primary antibody: P10568(ABHD16A Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

ABHD16A (Abhydrolase Domain-Containing 16A) is an enzyme belonging to the α/β-hydrolase superfamily, characterized by a conserved catalytic triad involved in hydrolytic activities. It is implicated in lipid metabolism, particularly in the regulation of phosphatidylserine (PS) and bis(monoacylglycerol)phosphate (BMP), lipids critical for cellular membrane dynamics and lysosomal function. ABHD16A is also identified as a co-factor for the phospholipase DDHD2. influencing lipid signaling pathways. Dysregulation of ABHD16A has been linked to neurological disorders and lysosomal storage diseases, highlighting its biological relevance.

Antibodies targeting ABHD16A are essential tools for studying its expression, localization, and functional roles. These antibodies are typically validated in applications such as Western blotting, immunofluorescence, and immunoprecipitation. Specificity is confirmed using knockout cell lines or tissues to avoid cross-reactivity with homologous proteins. Epitope mapping often focuses on unique regions, such as the C-terminal domain, to ensure precise detection. Recent studies employ ABHD16A antibodies to explore its interaction with lipid substrates, its role in neuroinflammatory processes, and potential therapeutic targets in metabolic or neurodegenerative diseases. Reliable ABHD16A antibodies thus support advancing research into lipid biology and associated pathologies.