DHX38抗體,Rabbit Polyclonal DHX38 Antibody

DHX38抗體—艾普蒂

價(jià)格	詢價(jià)
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	上海
更新日期	2025-05-21

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產(chǎn)品詳情

中文名稱:DHX38抗體	英文名稱:Rabbit Polyclonal DHX38 Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5552 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Rabbit
偶聯(lián)物: 無(wú)	靶點(diǎn): DHX38

驗(yàn)證與應(yīng)用

應(yīng)用及物種

WB	咨詢技術(shù)	Human,Mouse,Rat
IF	咨詢技術(shù)	Human,Mouse,Rat
IHC	1/100-1/300	Human,Mouse,Rat
ICC	技術(shù)咨詢	Human,Mouse,Rat
FCM	咨詢技術(shù)	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

產(chǎn)品詳情

Aliases	RP84; DDX38; PRP16; PRPF16
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human DHX38
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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The image is immunohistochemistry of paraffin-embedded Human brain tissue using P10468(DHX38 Antibody) at dilution 1/105. (Original magnification: ×200)

參考文獻(xiàn)

以下是關(guān)于DHX38抗體的3篇參考文獻(xiàn)示例(注：以下內(nèi)容為示例性虛構(gòu)，實(shí)際文獻(xiàn)需通過(guò)學(xué)術(shù)數(shù)據(jù)庫(kù)查詢)：

1. **"DHX38 is essential for spliceosome assembly and Pre-mRNA splicing in human cells"**

- **作者**: Smith J, et al.

- **摘要**: 本研究通過(guò)CRISPR/Cas9敲低DHX38基因，結(jié)合DHX38特異性抗體進(jìn)行免疫共沉淀(Co-IP)和Western blot分析，發(fā)現(xiàn)DHX38在剪接體動(dòng)態(tài)組裝中起關(guān)鍵作用，其缺失導(dǎo)致mRNA前體剪接異常和細(xì)胞周期停滯。

2. **"A novel monoclonal antibody against DHX38 reveals its overexpression in colorectal cancer tissues"**

- **作者**: Zhang L, et al.

- **摘要**: 文章報(bào)道了一種高特異性抗DHX38單克隆抗體的開(kāi)發(fā)，并通過(guò)免疫組織化學(xué)(IHC)證實(shí)DHX38在結(jié)直腸癌組織中顯著高表達(dá)，提示其可能作為癌癥診斷或預(yù)后的潛在標(biāo)志物。

3. **"DHX38 interacts with viral RNA to regulate host antiviral responses"**

- **作者**: Johnson M, et al.

- **摘要**: 利用DHX38多克隆抗體進(jìn)行免疫熒光和RNA結(jié)合實(shí)驗(yàn)，揭示了DHX38在識(shí)別病毒RNA并激活天然免疫信號(hào)通路(如RIG-I/MAVS)中的功能，為抗病毒治療提供了新靶點(diǎn)。

4. **"Characterization of DHX38 polyclonal antibody for functional studies in zebrafish models"**

- **作者**: Lee S, et al.

- **摘要**: 該研究驗(yàn)證了一種適用于斑馬魚(yú)模型的DHX38多克隆抗體，通過(guò)Western blot和免疫組化證明其跨物種反應(yīng)性，并發(fā)現(xiàn)DHX38缺失導(dǎo)致斑馬魚(yú)胚胎發(fā)育缺陷，強(qiáng)調(diào)了其進(jìn)化保守性功能。

如需真實(shí)文獻(xiàn)，建議在PubMed或Google Scholar中檢索關(guān)鍵詞“DHX38 antibody”或“DHX38 function”。

背景信息

The DHX38 antibody is a crucial tool for studying the DEAH-box helicase DHX38. a protein involved in pre-mRNA splicing and genome stability. DHX38. also known as PRP16 homolog, plays a key role in the catalytic activation of the spliceosome during the splicing cycle, facilitating the release of lariat introns and ensuring accurate RNA processing. It is implicated in diverse cellular processes, including cell cycle regulation, DNA repair, and neuronal development. Dysregulation of DHX38 has been linked to diseases such as retinitis pigmentosa and cancer. Researchers utilize DHX38 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions with spliceosomal components. These antibodies are typically raised in rabbits or mice against specific epitopes of the human DHX38 protein, with validation in knockout models to ensure specificity. Recent studies also explore DHX38's role in alternative splicing events linked to neurodegeneration and its potential as a therapeutic target. The antibody's applications extend to clinical research, particularly in analyzing splicing defects in genetic disorders and cancer biology.

關(guān)鍵字： DHX38抗體;DHX38;DHX38 Antibody;

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