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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10438(KLF12 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

**Background of KLF12 Antibody**

The KLF12 (Krüppel-like factor 12) antibody is a research tool designed to detect and study the KLF12 protein, a member of the Krüppel-like factor family of transcription regulators. KLF12 contains conserved C-terminal zinc-finger DNA-binding domains and functions primarily as a transcriptional repressor. It plays roles in diverse biological processes, including cell differentiation, proliferation, and apoptosis. KLF12 is notably involved in cancer biology, where it may act as a tumor suppressor by inhibiting oncogenic pathways. For example, it suppresses AP-2α-mediated transcription in certain cancers, impacting tumor progression.

KLF12 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP) to investigate KLF12 expression patterns, subcellular localization, and DNA-binding interactions. These antibodies are critical for elucidating KLF12's regulatory mechanisms in development and disease. Validation often includes testing in KLF12-knockout cell lines to confirm specificity. Commercial KLF12 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein. Researchers rely on these reagents to explore KLF12's role in pathologies such as cancers, metabolic disorders, and neurological conditions, making it a valuable tool in molecular and clinical research.