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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HUVEC, PC-3 cell lysates, Primary antibody: P10423(SAV1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P10423(SAV1 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10423(SAV1 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

SAV1 (Salvador homolog 1) is a key regulatory protein in the Hippo signaling pathway, a conserved signaling network critical for controlling organ size, tissue homeostasis, and tumor suppression. It functions as a scaffolding protein that facilitates interactions between kinases MST1/2 (Mammalian Ste20-like kinases) and LATS1/2 (Large Tumor Suppressor kinases), thereby promoting phosphorylation cascades that ultimately inhibit the transcriptional co-activators YAP (Yes-associated protein) and TAZ (Transcriptional co-activator with PDZ-binding motif). Dysregulation of SAV1 or the Hippo pathway is implicated in cancer, organomegaly, and regenerative disorders.

SAV1 antibodies are essential tools for studying Hippo pathway dynamics, enabling detection of SAV1 expression, localization, and interaction partners in various experimental models. Researchers use these antibodies in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to explore SAV1's role in cell proliferation, apoptosis, and tissue development. Studies have linked SAV1 loss or mutations to tumor progression, making it a biomarker of interest in cancers such as hepatocellular carcinoma and colorectal cancer. Commercially available SAV1 antibodies are typically validated for specificity across human, mouse, and rat samples, with applications in both basic research and therapeutic target validation. Understanding SAV1-mediated signaling provides insights into organ regeneration strategies and cancer therapeutics targeting Hippo pathway components.