CSRP2 (Cysteine and Glycine-Rich Protein 2), also known as CRP2. is a member of the CSRP family characterized by LIM domains that mediate protein-protein interactions. It plays regulatory roles in cellular processes such as cytoskeletal organization, cell migration, differentiation, and tissue development, particularly in cardiac and skeletal muscle. Studies highlight its involvement in embryogenesis, with mouse models showing CSRP2 knockout leading to cardiovascular defects. Dysregulation of CSRP2 has been linked to cancer progression, fibrosis, and metabolic disorders, making it a focus in disease research.
CSRP2 antibodies are essential tools for detecting and quantifying CSRP2 expression in research. Commonly generated in hosts like rabbits or mice, these antibodies are validated for applications including Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate CSRP2's subcellular localization (nuclear/cytoplasmic) and its interaction networks. Specificity is critical due to homology with other LIM-domain proteins (e.g., CSRP1/CSRP3), requiring rigorous validation to avoid cross-reactivity. In cancer studies, CSRP2 antibodies aid in exploring its dual roles—acting as a tumor suppressor or promoter depending on context—and its potential as a diagnostic biomarker or therapeutic target. Ongoing research continues to expand their utility in both basic and translational biomedical fields.