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GMDS抗體,Rabbit Polyclonal GMDS Antibody
  • GMDS抗體,Rabbit Polyclonal GMDS Antibody
  • GMDS抗體,Rabbit Polyclonal GMDS Antibody
  • GMDS抗體,Rabbit Polyclonal GMDS Antibody

GMDS抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GMDS抗體英文名稱:Rabbit Polyclonal GMDS Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5302 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: GMDS
2025-05-21 GMDS抗體 Rabbit Polyclonal GMDS Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5302 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGMD; SDR3E1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human GMDS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10125(GMDS Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10125(GMDS Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于GMDS抗體的3篇參考文獻(xiàn)示例(注:以下為模擬內(nèi)容,實際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫查詢):

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1. **文獻(xiàn)名稱**:*GMDS Antibody-Based Detection of Aberrant Glycosylation in Colorectal Cancer*

**作者**:Smith A, et al.

**摘要**:本研究開發(fā)了一種高特異性GMDS單克隆抗體,用于檢測結(jié)直腸癌組織中GDP-甘露糖4.6-脫水酶(GMDS)的表達(dá)水平。通過免疫組化分析發(fā)現(xiàn),GMDS在腫瘤組織中的表達(dá)顯著下調(diào),且與患者預(yù)后不良相關(guān),提示其可能作為癌癥診斷的潛在生物標(biāo)志物。

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2. **文獻(xiàn)名稱**:*GMDS Deficiency Enhances Tumor Immune Evasion via Altered N-Glycosylation*

**作者**:Wang L, et al.

**摘要**:文章利用GMDS抗體探究了GMDS缺失對腫瘤細(xì)胞表面糖基化的影響。實驗表明,GMDS缺陷導(dǎo)致細(xì)胞表面聚糖結(jié)構(gòu)改變,抑制T細(xì)胞對腫瘤的識別,從而促進(jìn)免疫逃逸。該發(fā)現(xiàn)為靶向糖代謝的免疫治療提供了新思路。

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3. **文獻(xiàn)名稱**:*Development of a GMDS Polyclonal Antibody for Functional Studies in Plant Cells*

**作者**:Rodriguez M, et al.

**摘要**:研究報道了一種針對植物GMDS酶的多克隆抗體制備方法,并通過Western blot和免疫熒光驗證其特異性。該抗體成功應(yīng)用于擬南芥模型中,揭示了GMDS在植物細(xì)胞壁多糖合成中的關(guān)鍵作用。

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如需具體文獻(xiàn),建議通過PubMed、Google Scholar等平臺以“GMDS antibody”或“GDP-mannose 4.6-dehydratase”為關(guān)鍵詞檢索。

       

背景信息

GMDS (GDP-mannose 4.6-dehydratase) is a key enzyme in the biosynthesis of fucose, a sugar critical for protein glycosylation. It catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, a precursor for GDP-fucose, which is essential for post-translational modification of glycoproteins and glycolipids. Fucosylated molecules play vital roles in cell adhesion, immune response, and signal transduction. Dysregulation of GMDS has been implicated in cancer metastasis, inflammation, and autoimmune disorders due to altered fucosylation patterns affecting cell-cell interactions or immune recognition.

GMDS antibodies are tools used to study the enzyme's expression, localization, and function in biological systems. They are critical in detecting GMDS protein levels in tissues or cell lines, often applied in techniques like Western blot, immunohistochemistry, or flow cytometry. Such antibodies help explore GMDS-related pathways in diseases; for example, reduced GMDS expression in certain cancers correlates with poor prognosis. Researchers also utilize GMDS antibodies to validate gene knockout models or assess therapeutic interventions targeting fucose metabolism. Commercially available GMDS antibodies are typically raised against specific epitopes, with validation in cross-reactivity (human, mouse, rat) and application-specific contexts. Their development supports both basic research and potential diagnostic applications, particularly in understanding glycosylation disorders.

       
關(guān)鍵字: GMDS抗體;GMDS;GMDS Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

GMDS抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥1950
VIP3年
上海滬震實業(yè)有限公司
2025-08-01
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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