The PSMB2 (Proteasome 20S Subunit Beta 2) antibody is a research tool used to detect and study the PSMB2 protein, a critical component of the 20S core proteasome complex. The proteasome is a multi-subunit protease responsible for degrading ubiquitinated proteins, a process essential for maintaining cellular homeostasis, regulating cell cycle progression, and managing stress responses. PSMB2. as part of the β-subunit family, contributes to the proteolytic activity of the 20S core, which is involved in the ATP-independent degradation of misfolded or damaged proteins.
Antibodies targeting PSMB2 enable researchers to investigate its expression, localization, and function in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cultured cells. Dysregulation of proteasome activity, including PSMB2 expression, has been linked to diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. For instance, altered proteasome function may promote tumor survival or contribute to the accumulation of toxic protein aggregates in Alzheimer's or Parkinson's disease.
Additionally, PSMB2 antibodies aid in studying the efficacy of proteasome inhibitors, a class of anticancer drugs. Understanding PSMB2's role in proteostasis provides insights into cellular stress adaptation and potential therapeutic targets for proteasome-related pathologies.