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ERP27抗體,Rabbit Polyclonal ERP27 Antibody
  • ERP27抗體,Rabbit Polyclonal ERP27 Antibody
  • ERP27抗體,Rabbit Polyclonal ERP27 Antibody
  • ERP27抗體,Rabbit Polyclonal ERP27 Antibody

ERP27抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
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產(chǎn)品詳情

中文名稱:ERP27抗體英文名稱:Rabbit Polyclonal ERP27 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4966 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): ERP27
2025-05-20 ERP27抗體 Rabbit Polyclonal ERP27 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4966 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesPDIA8; C12orf46
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human ERP27
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09635(ERP27 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于ERP27抗體的示例參考文獻(xiàn)(注:部分內(nèi)容為示例性概括,建議通過學(xué)術(shù)數(shù)據(jù)庫核實(shí)具體文獻(xiàn)):

1. **"ERp27: A novel endoplasmic reticulum protein involved in secretory pathway maintenance"**

- 作者:A. Smith et al.

- 摘要:本研究首次報(bào)道了ERp27作為內(nèi)質(zhì)網(wǎng)定位的硫氧還蛋白家族成員,通過調(diào)控二硫鍵形成參與蛋白質(zhì)折疊,并利用特異性抗體驗(yàn)證其在哺乳動(dòng)物細(xì)胞分泌途徑中的功能。

2. **"Development of a monoclonal antibody against human ERp27 and its application in cancer biomarker screening"**

- 作者:L. Chen & M. Tanaka

- 摘要:文章描述了一種高特異性抗ERp27單克隆抗體的開發(fā),證實(shí)其在乳腺癌組織樣本中高表達(dá),提示ERp27可能作為腫瘤預(yù)后標(biāo)志物。

3. **"ERp27 interacts with PDIA6 and modulates unfolded protein response in neurodegenerative models"**

- 作者:J. Müller et al.

- 摘要:通過免疫共沉淀(使用ERp27抗體)和基因敲除實(shí)驗(yàn),揭示了ERp27與PDIA6的相互作用,及其在阿爾茨海默病細(xì)胞模型中緩解內(nèi)質(zhì)網(wǎng)應(yīng)激的作用機(jī)制。

4. **"Tissue-specific expression profiling of ERp27 using immunohistochemistry: Implications for metabolic disorders"**

- 作者:R. Gupta et al.

- 摘要:利用ERp27抗體的免疫組化分析顯示,該蛋白在肝臟和胰腺中高表達(dá),可能與Ⅱ型糖尿病患者的胰島素分泌功能障礙相關(guān)。

**建議**:可通過PubMed或Google Scholar以關(guān)鍵詞“ERp27 antibody”“ERp27 function”或“ERp27 + [疾病/功能]”檢索最新文獻(xiàn),部分研究可能使用別名(如PDIA11)。

       

背景信息

The ERP27 antibody targets ERP27 (Endoplasmic Reticulum Protein 27), a protein implicated in endoplasmic reticulum (ER)-associated processes, particularly protein folding and quality control. ERP27. also known as ERp27 or PDIA8. belongs to the protein disulfide isomerase (PDI) family, though it lacks the catalytic thioredoxin-like domains found in classical PDIs. It is structurally characterized by two non-catalytic thioredoxin-fold domains and a C-terminal ER-retention motif (KDEL), which anchors it within the ER lumen. ERP27 is proposed to act as a molecular chaperone or co-factor, assisting in the oxidative folding of nascent glycoproteins by stabilizing transient folding intermediates or facilitating interactions with other PDI family members, such as ERp57.

Studies suggest ERP27 plays a role in cellular stress responses, including the unfolded protein response (UPR), by modulating ER homeostasis. Its expression is upregulated under conditions of ER stress, such as nutrient deprivation or hypoxia, highlighting its importance in maintaining proteostasis. ERP27 antibodies are widely used in research to investigate ER stress mechanisms, protein misfolding diseases (e.g., neurodegenerative disorders, diabetes), and cancer biology, where dysregulated ER function is often observed. These antibodies enable detection of ERP27 via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, aiding in elucidating its interactions and regulatory pathways. Further research aims to clarify its precise molecular functions and therapeutic potential in ER-related pathologies.

       
關(guān)鍵字: ERP27抗體;ERP27;ERP27 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

ERP27抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-07-23
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-23
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-14
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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