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DENND1B抗體,Rabbit Polyclonal DENND1B Antibody
  • DENND1B抗體,Rabbit Polyclonal DENND1B Antibody
  • DENND1B抗體,Rabbit Polyclonal DENND1B Antibody
  • DENND1B抗體,Rabbit Polyclonal DENND1B Antibody

DENND1B抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DENND1B抗體英文名稱:Rabbit Polyclonal DENND1B Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4956 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: DENND1B
2025-05-20 DENND1B抗體 Rabbit Polyclonal DENND1B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4956 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesFAM31B; C1ORF18; C1orf218
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DENND1B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09617(DENND1B Antibody) at dilution 1/100. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于DENND1B抗體的3篇參考文獻(xiàn)示例(注:文獻(xiàn)為假設(shè)性概括,實際文獻(xiàn)需通過數(shù)據(jù)庫查詢確認(rèn)):

1. **標(biāo)題**: *DENND1B Variants Regulate Th2 Cell-Mediated Airway Inflammation*

**作者**: Larose et al.

**摘要**: 研究發(fā)現(xiàn)了DENND1B基因多態(tài)性與兒童哮喘的關(guān)聯(lián),通過抗體檢測發(fā)現(xiàn)DENND1B蛋白在T細(xì)胞中高表達(dá),并調(diào)控Th2細(xì)胞因子的分泌,影響氣道炎癥反應(yīng)。

2. **標(biāo)題**: *DENND1B Functions as a Guanine Nucleotide Exchange Factor in Rab35 Signaling*

**作者**: McNamara et al.

**摘要**: 利用DENND1B特異性抗體進(jìn)行免疫沉淀實驗,揭示了DENND1B作為Rab35 GTP酶的激活因子,參與細(xì)胞膜運(yùn)輸和突觸形成,為神經(jīng)發(fā)育疾病機(jī)制提供依據(jù)。

3. **標(biāo)題**: *DENND1B Expression in Autoimmune Thyroid Disease*

**作者**: O'Connell et al.

**摘要**: 通過Western blot和免疫組化分析,發(fā)現(xiàn)DENND1B抗體在甲狀腺濾泡細(xì)胞中的異常表達(dá)與Graves病相關(guān),提示其在自身免疫調(diào)控中的作用。

4. **標(biāo)題**: *DENND1B Mutation Analysis in Pediatric Immune Dysregulation*

**作者**: Puffenberger et al.

**摘要**: 研究利用DENND1B抗體驗證患者突變體的蛋白表達(dá)缺失,發(fā)現(xiàn)其與早發(fā)型免疫失調(diào)綜合征相關(guān),強(qiáng)調(diào)該基因在淋巴細(xì)胞功能中的關(guān)鍵性。

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**提示**:以上為模擬示例,真實文獻(xiàn)請通過PubMed或Google Scholar搜索關(guān)鍵詞“DENND1B antibody”或“DENND1B function”獲取。

       

背景信息

DENND1B (Differentially Expressed in Normal and Neoplastic Cells Domain 1B) is a member of the DENN domain-containing protein family, which plays critical roles in intracellular membrane trafficking and signal transduction. The DENND1B gene encodes a guanine nucleotide exchange factor (GEF) that activates Rab GTPases, particularly Rab35. regulating vesicle formation, receptor recycling, and cytokine secretion. DENND1B is implicated in immune regulation, neurodevelopment, and cancer progression, with studies linking its genetic variants to asthma, autoimmune diseases, and neurodevelopmental disorders.

DENND1B antibodies are essential tools for studying the protein's expression, localization, and function in cellular and disease contexts. These antibodies enable detection of DENND1B via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using DENND1B-specific antibodies has revealed its involvement in T-cell receptor signaling, dendritic cell maturation, and synaptic vesicle trafficking. In cancer, DENND1B overexpression has been associated with tumor growth and metastasis in certain malignancies. The antibody's applications extend to validating CRISPR/Cas9 knockout models and exploring DENND1B-Rab35 pathway dysregulation in pathological conditions. Commercially available DENND1B antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown, ensuring reliability in experimental settings.

       
關(guān)鍵字: DENND1B抗體;DENND1B;DENND1B Antibody;

公司簡介

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員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

DENND1B抗體—艾普蒂相關(guān)廠家報價

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維百奧(北京)生物科技有限公司
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