**Background of CMPK1 Antibody**
CMPK1 (cytidine/uridine monophosphate kinase 1) is a nucleoside monophosphate kinase that plays a critical role in pyrimidine nucleotide metabolism by catalyzing the phosphorylation of cytidine/uridine monophosphates (CMP/UMP) to their diphosphate forms (CDP/UDP). This enzyme is essential for maintaining nucleotide pools required for DNA/RNA synthesis and cellular energy homeostasis. CMPK1 is localized in mitochondria and the cytosol, linking it to mitochondrial function and cellular proliferation. Dysregulation of CMPK1 has been implicated in various pathologies, including viral infections, cancer progression, and metabolic disorders.
CMPK1 antibodies are immunological tools designed to detect and quantify CMPK1 protein levels in research applications. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CMPK1 expression, subcellular localization, and interactions. They enable investigations into CMPK1's role in mitochondrial DNA synthesis, antiviral responses (e.g., in HIV or hepatitis B), and its potential as a biomarker in cancers like hepatocellular carcinoma.
Validated CMPK1 antibodies are critical for ensuring specificity, often confirmed via knockout controls or siRNA silencing. Their development supports advancing studies on nucleotide metabolism, antiviral therapies, and cancer mechanisms, making them valuable in both basic and translational research.