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CHCHD3抗體,Rabbit Polyclonal CHCHD3 Antibody
  • CHCHD3抗體,Rabbit Polyclonal CHCHD3 Antibody
  • CHCHD3抗體,Rabbit Polyclonal CHCHD3 Antibody
  • CHCHD3抗體,Rabbit Polyclonal CHCHD3 Antibody

CHCHD3抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CHCHD3抗體英文名稱:Rabbit Polyclonal CHCHD3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4868 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CHCHD3
2025-05-20 CHCHD3抗體 Rabbit Polyclonal CHCHD3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4868 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMic19; MINOS3; PPP1R22
WB Predicted band size26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HEPG2, A549 and 293T cell lysates, Primary antibody: P09494(CHCHD3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09494(CHCHD3 Antibody) at dilution 1/45. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09494(CHCHD3 Antibody) at dilution 1/45. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于CHCHD3抗體的3篇參考文獻(xiàn)示例(注:部分文獻(xiàn)信息為虛構(gòu),僅作格式參考):

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1. **文獻(xiàn)名稱**:*CHCHD3 maintains mitochondrial cristae structure and interacts with the MICOS complex*

**作者**:Anderson, C.J., et al.

**摘要**:本研究利用CHCHD3特異性抗體(Western blot/IF)揭示了CHCHD3在線粒體嵴形態(tài)維持中的關(guān)鍵作用,并證實其與MICOS復(fù)合體的相互作用,調(diào)控線粒體內(nèi)膜結(jié)構(gòu)。

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2. **文獻(xiàn)名稱**:*Loss of CHCHD3 impairs mitochondrial respiration and promotes Parkinson’s disease-related pathology*

**作者**:Smith, L., et al.

**摘要**:通過CHCHD3抗體檢測人腦組織樣本,發(fā)現(xiàn)帕金森病患者CHCHD3表達(dá)顯著降低。功能實驗表明,CHCHD3缺失導(dǎo)致線粒體呼吸鏈復(fù)合體活性受損,加劇神經(jīng)元退化。

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3. **文獻(xiàn)名稱**:*Generation and validation of a polyclonal antibody targeting human CHCHD3 for mitochondrial studies*

**作者**:Zhang, Y., et al.

**摘要**:本文報道了一種針對人源CHCHD3蛋白的多克隆抗體的開發(fā),通過免疫兔獲得抗體,并經(jīng)ELISA、免疫沉淀和免疫熒光驗證其特異性,為線粒體蛋白研究提供新工具。

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(注:以上文獻(xiàn)為示例,實際引用時請核實真實文獻(xiàn)信息。)

       

背景信息

CHCHD3 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3) is a mitochondrial protein belonging to the CHCHD family, characterized by twin CHCH domains that mediate protein-protein interactions and subcellular localization. Primarily located in the mitochondrial intermembrane space, CHCHD3 plays a critical role in maintaining cristae structure, mitochondrial membrane integrity, and oxidative phosphorylation. It interacts with the MICOS (mitochondrial contact site and cristae organizing system) complex, which governs mitochondrial morphology and function. Dysregulation of CHCHD3 has been linked to mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s), and cancer due to its influence on apoptosis and metabolic reprogramming.

CHCHD3 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess CHCHD3 levels in disease models or tissue samples. Specific antibodies help identify CHCHD3’s dual role in mitochondrial dynamics and nuclear signaling under stress conditions. Commercial antibodies are typically validated using knockout cell lines or siRNA silencing to ensure specificity. Research utilizing these antibodies has advanced understanding of mitochondrial pathophysiology, particularly in contexts of energy metabolism defects and age-related degeneration. However, challenges remain in standardizing antibody performance across experimental platforms, emphasizing the need for rigorous validation in diverse biological systems.

       
關(guān)鍵字: CHCHD3抗體;CHCHD3;CHCHD3 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

CHCHD3抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
¥1950
VIP3年
上海滬震實業(yè)有限公司
2025-08-01
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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