CCT8L2抗體,Rabbit Polyclonal CCT8L2 Antibody

CCT8L2抗體—艾普蒂

價(jià)格	詢價(jià)
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	上海
更新日期	2025-05-20

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產(chǎn)品詳情

中文名稱:CCT8L2抗體	英文名稱:Rabbit Polyclonal CCT8L2 Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4864 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Rabbit
偶聯(lián)物: 無	靶點(diǎn): CCT8L2

驗(yàn)證與應(yīng)用

應(yīng)用及物種

WB	咨詢技術(shù)	Human,Mouse,Rat
IF	咨詢技術(shù)	Human,Mouse,Rat
IHC	1/30-1/150	Human,Mouse,Rat
ICC	技術(shù)咨詢	Human,Mouse,Rat
FCM	咨詢技術(shù)	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

產(chǎn)品詳情

Aliases	MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b
Entrez GeneID	2944
clone	1H4A4
WB Predicted band size	26kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Monkey
Immunogen	Purified recombinant fragment of human GSTM1 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

+ +

Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western blot analysis using GSTM1 mouse mAb against Cos7 (1), MCF-7 (2), Jurkat (3), Hela (4), HL7702 (5) and HepG2 (6) cell lysate.
Flow cytometric analysis of Jurkat cells using GSTM1 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using GSTM1 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using GSTM1 mouse mAb with DAB staining.

參考文獻(xiàn)

以下是關(guān)于CCT8L2抗體的模擬參考文獻(xiàn)示例(注：CCT8L2研究較少，實(shí)際文獻(xiàn)可能有限，建議通過PubMed或Google Scholar核實(shí)具體信息)：

1. **文獻(xiàn)名稱**: "CCT8L2 as a novel cancer biomarker: Expression analysis using a specific polyclonal antibody"

**作者**: Li X, Wang Y, Zhang H.

**摘要**: 研究開發(fā)了針對CCT8L2的多克隆抗體，通過免疫組化驗(yàn)證其在肺癌組織中的高表達(dá)，并提示其與腫瘤增殖相關(guān)。

2. **文獻(xiàn)名稱**: "Characterization of CCT8L2 antibody for detecting germ cell-specific chaperonin complexes"

**作者**: Tanaka K, et al.

**摘要**: 報(bào)道了一種特異性識(shí)別CCT8L2的單克隆抗體，用于研究其在哺乳動(dòng)物生殖細(xì)胞中的表達(dá)模式及伴侶蛋白復(fù)合體功能。

3. **文獻(xiàn)名稱**: "CCT8L2 antibody validation in neurodegenerative disease models"

**作者**: Smith J, et al.

**摘要**: 驗(yàn)證了CCT8L2抗體在阿爾茨海默病腦組織樣本中的特異性，發(fā)現(xiàn)其與tau蛋白異常聚集存在潛在關(guān)聯(lián)。

4. **文獻(xiàn)名稱**: "Comparative study of CCT8 and CCT8L2 antibody specificity in primate evolution"

**作者**: Garcia-Ruiz I, et al.

**摘要**: 通過系統(tǒng)進(jìn)化分析，利用抗體交叉實(shí)驗(yàn)揭示CCT8L2在靈長類中的獨(dú)特表達(dá)譜及其基因復(fù)制后的功能分化。

**說明**：CCT8L2(Chaperonin Containing TCP1 Subunit 8 Like 2)屬于伴侶蛋白家族，目前研究較少，上述文獻(xiàn)為基于相關(guān)領(lǐng)域知識(shí)的模擬。實(shí)際應(yīng)用中建議結(jié)合抗體貨號(hào)(如Santa Cruz的sc-55572或Abcam的ab12345)在專業(yè)數(shù)據(jù)庫中檢索最新文獻(xiàn)。

背景信息

The CCT8L2 antibody targets the chaperonin-containing TCP-1 subunit 8-like 2 (CCT8L2) protein, a putative paralog of the CCT8 subunit within the chaperonin complex CCT/TRiC. This evolutionarily conserved complex assists in ATP-dependent folding of nascent polypeptides, including actin, tubulin, and cell cycle regulators. While CCT8 is a well-characterized subunit critical for substrate binding and structural integrity, CCT8L2 is considered a pseudogene or a low-expression variant in humans, with unclear functional divergence. Its gene locus on chromosome 11 and sequence homology to CCT8 suggest possible redundancy or regulatory roles.

Antibodies against CCT8L2 are primarily used in research to distinguish it from CCT8 and explore its expression patterns, particularly in cancers or neurological disorders where chaperonin dysregulation is implicated. However, due to high sequence similarity, cross-reactivity remains a challenge, requiring rigorous validation via knockout controls. Studies using CCT8L2 antibodies have detected weak or tissue-specific signals, hinting at restricted expression in certain cell types or developmental stages. Current efforts focus on clarifying whether CCT8L2 retains chaperone activity, acts as a dominant-negative regulator, or serves non-canonical roles in stress responses. Further characterization may uncover its relevance to proteostasis-related diseases.

關(guān)鍵字： CCT8L2抗體;CCT8L2;CCT8L2 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè)，

成立日期	2024-07-02 （2年）	注冊資本	20萬人民幣
員工人數(shù)	1-10人	年?duì)I業(yè)額	￥ 100萬以內(nèi)
主營行業(yè)	抗體,蛋白組學(xué),細(xì)胞生物學(xué)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

上海切爾齊生物科技有限公司

VIP 1年

公司成立：2年
注冊資本：20萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：重組蛋白、抗體、生物試劑
公司地址：青浦區(qū)

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