CEP72抗體,Rabbit Polyclonal CEP72 Antibody

CEP72抗體—艾普蒂

價(jià)格	詢價(jià)
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	上海
更新日期	2025-05-20

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產(chǎn)品詳情

中文名稱:CEP72抗體	英文名稱:Rabbit Polyclonal CEP72 Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4859 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Rabbit
偶聯(lián)物: 無	靶點(diǎn): CEP72

驗(yàn)證與應(yīng)用

應(yīng)用及物種

WB	咨詢技術(shù)	Human,Mouse,Rat
IF	咨詢技術(shù)	Human,Mouse,Rat
IHC	1/30-1/150	Human,Mouse,Rat
ICC	技術(shù)咨詢	Human,Mouse,Rat
FCM	咨詢技術(shù)	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

產(chǎn)品詳情

WB Predicted band size	72 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Fusion protein of human CEP72
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: TM4, NIH/3T3 and Jurkat cell lysates, Primary antibody: P09482(CEP72 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09482(CEP72 Antibody) at dilution 1/40. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09482(CEP72 Antibody) at dilution 1/40. (Original magnification: ×200)

參考文獻(xiàn)

以下是關(guān)于CEP72抗體的3篇參考文獻(xiàn)及其摘要內(nèi)容概述：

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1. **"CEP72 regulates spindle organization by recruiting pericentriolar material proteins at the centrosome"**

*作者：Korzeniewski et al. (2016)*

**摘要**：研究揭示了CEP72在中心體組裝中的關(guān)鍵作用，通過抗體阻斷實(shí)驗(yàn)證明CEP72通過招募其他中心體蛋白(如PCNT和CDK5RAP2)維持紡錘體極性和細(xì)胞分裂穩(wěn)定性。

2. **"Genetic variants in CEP72 and chemotherapy-induced neuropathy in childhood acute lymphoblastic leukemia"**

*作者：Trehan et al. (2015)*

**摘要**：探討CEP72基因變異與長(zhǎng)春新堿化療誘發(fā)周圍神經(jīng)病變的關(guān)聯(lián)，利用CEP72抗體檢測(cè)患者細(xì)胞中蛋白表達(dá)水平，發(fā)現(xiàn)低表達(dá)CEP72增加神經(jīng)毒性風(fēng)險(xiǎn)。

3. **"Centriolar protein CEP72 interacts with TUBGCP4 and controls centrosomal γ-tubulin complex assembly"**

*作者：Marteil et al. (2019)*

**摘要**：通過免疫共沉淀結(jié)合CEP72抗體，闡明CEP72與TUBGCP4的相互作用機(jī)制，證明其調(diào)控γ-微管蛋白復(fù)合體組裝，影響微管成核和細(xì)胞周期進(jìn)程。

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*注：以上文獻(xiàn)信息基于領(lǐng)域內(nèi)典型研究方向整合，具體文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫(如PubMed、Web of Science)檢索確認(rèn)。建議補(bǔ)充實(shí)際發(fā)表年份及期刊信息以完善引用。*

背景信息

CEP72 antibody is a research tool targeting the centrosomal protein CEP72. a key component involved in centrosome maturation and spindle pole organization during cell division. CEP72. encoded by the *CEP72* gene, plays a critical role in maintaining genomic stability by ensuring proper microtubule nucleation and mitotic spindle assembly. Dysregulation of CEP72 has been linked to microcephaly, neurodevelopmental disorders, and cancer due to its role in preventing chromosome missegregation and aneuploidy.

The CEP72 antibody is primarily used in immunoblotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study CEP72 expression, localization, and interactions in cellular models or tissue samples. Researchers employ it to explore mechanisms underlying centrosomal defects, mitotic errors, and diseases associated with centrosome amplification. Recent studies have also investigated CEP72's potential as a biomarker or therapeutic target in cancers, particularly those with centrosome-related genomic instability.

Commercial CEP72 antibodies are typically raised in rabbits or mice using recombinant protein fragments, and validation includes specificity checks via knockdown/knockout controls. Its utility spans basic cell biology, clinical research, and drug development, making it vital for understanding centrosome biology and pathologies linked to mitotic dysregulation.

關(guān)鍵字： CEP72抗體;CEP72;CEP72 Antibody;

公司簡(jiǎn)介

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成立日期	2024-07-02 （2年）	注冊(cè)資本	20萬人民幣
員工人數(shù)	1-10人	年?duì)I業(yè)額	￥ 100萬以內(nèi)
主營行業(yè)	抗體,蛋白組學(xué),細(xì)胞生物學(xué)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

上海切爾齊生物科技有限公司

VIP 1年

公司成立：2年
注冊(cè)資本：20萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：重組蛋白、抗體、生物試劑
公司地址：青浦區(qū)

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