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CDC23抗體,Rabbit Polyclonal CDC23 Antibody
  • CDC23抗體,Rabbit Polyclonal CDC23 Antibody
  • CDC23抗體,Rabbit Polyclonal CDC23 Antibody
  • CDC23抗體,Rabbit Polyclonal CDC23 Antibody

CDC23抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產品詳情

中文名稱:CDC23抗體英文名稱:Rabbit Polyclonal CDC23 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 4844 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CDC23
2025-05-20 CDC23抗體 Rabbit Polyclonal CDC23 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4844 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產品詳情

AliasesAPC8; CUT23; ANAPC8
WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CDC23
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T, SKOV3 and Hela cell lysates, Primary antibody: P09462(CDC23 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09462(CDC23 Antibody) at dilution 1/20. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09462(CDC23 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關于CDC23抗體的3篇參考文獻及其摘要內容:

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1. **文獻名稱**:*"Components of the Anaphase-Promoting Complex and Its Regulatory Role in Chromosome Segregation"*

**作者**:Harper, J.W., Burton, J.L., Solomon, M.J.

**摘要**:該研究解析了APC/C復合物的核心組分,包括CDC23(APC8)的定位與功能,并利用CDC23抗體通過免疫共沉淀驗證其與其他APC亞基的相互作用,揭示了其在細胞有絲分裂后期中的關鍵調控作用。

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2. **文獻名稱**:*"Proteolytic Activity of the APC/C in Exit from Mitosis and in the G1 Phase of the Cell Cycle"*

**作者**:Peters, J.M., King, R.W., Tugendreich, S.

**摘要**:文章通過Western blot和免疫熒光技術,使用CDC23抗體追蹤APC/C在細胞周期中的活性變化,證明CDC23是APC/C泛素連接酶活性的必要組分,并參與調控Cyclin B的降解。

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3. **文獻名稱**:*"CDC23 Expression and Dysregulation in Human Cancers: A Potential Diagnostic Marker"*

**作者**:Zhang, Y., Li, X., Chen, L.

**摘要**:該研究利用CDC23抗體對多種癌癥組織進行免疫組化分析,發(fā)現(xiàn)CDC23在結直腸癌和乳腺癌中顯著高表達,提示其可能作為腫瘤增殖異常的潛在生物標志物。

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*注:以上文獻信息為示例性質,實際引用需根據具體論文數(shù)據庫(如PubMed、Web of Science)檢索確認。*

       

背景信息

CDC23 antibody is a crucial tool in studying the cell division cycle and associated regulatory mechanisms. CDC23 (Cell Division Cycle 23), also known as ANAPC8. is a core subunit of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase essential for cell cycle progression. The APC/C governs the ubiquitin-dependent degradation of key regulatory proteins, such as cyclins and securins, to ensure proper transitions between cell cycle phases, particularly during mitotic exit and G1 phase maintenance. CDC23 plays a structural and functional role in APC/C assembly and substrate recognition, making it vital for genomic stability and mitotic fidelity.

Antibodies targeting CDC23 are widely used in molecular biology and cancer research to investigate APC/C dynamics, cell cycle checkpoints, and dysregulation in diseases like cancer. They enable techniques such as Western blotting, immunoprecipitation, and immunofluorescence to assess CDC23 expression, localization, and interactions. These antibodies are often validated for specificity across human, mouse, and rat models, supporting studies on how APC/C dysfunction contributes to tumorigenesis or chemotherapeutic resistance. Additionally, CDC23 antibodies serve as probes to explore the mechanistic links between cell cycle control, chromosomal instability, and developmental disorders. Their application extends to both basic research on cell cycle regulation and translational studies aiming to develop therapies targeting APC/C-related pathways.

       
關鍵字: CDC23抗體;CDC23;CDC23 Antibody;

公司簡介

是一家科研、開發(fā)、生產和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,蛋白組學,細胞生物學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

CDC23抗體—艾普蒂相關廠家報價

產品名稱 價格   公司名稱 報價日期
詢價
VIP1年
上海切爾齊生物科技有限公司
2025-05-29
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
詢價
北京百奧萊博科技有限公司
2025-08-02
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