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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09391(TMEM256 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09391(TMEM256 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TMEM256 (Transmembrane Protein 256) gene encodes a poorly characterized protein predicted to localize to cellular membranes, potentially involved in intracellular signaling or organelle function. Though its exact biological role remains unclear, TMEM256 has been implicated in diverse processes, including cell proliferation, apoptosis, and mitochondrial dynamics. Studies suggest associations with diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, though mechanistic insights are limited.

TMEM256 antibodies are immunological tools developed to detect and study the expression, localization, and function of the TMEM256 protein. These antibodies are typically raised in hosts like rabbits or mice using peptide antigens derived from conserved regions of the human TMEM256 sequence. They enable applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Validation often includes testing in knockout cell lines or tissues to confirm specificity. Research utilizing TMEM256 antibodies has helped identify its subcellular distribution (e.g., mitochondrial or endoplasmic reticulum association) and explore its potential roles in pathological contexts, such as tumor progression or neuronal dysfunction. However, the antibody's utility is constrained by the incomplete understanding of TMEM256's biology, necessitating careful experimental controls. Commercial availability through suppliers like Abcam or Sigma-Aldeldrich supports broader accessibility for ongoing investigations.