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ASXL2抗體,Rabbit Polyclonal ASXL2 Antibody
  • ASXL2抗體,Rabbit Polyclonal ASXL2 Antibody
  • ASXL2抗體,Rabbit Polyclonal ASXL2 Antibody
  • ASXL2抗體,Rabbit Polyclonal ASXL2 Antibody

ASXL2抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產品詳情

中文名稱:ASXL2抗體英文名稱:Rabbit Polyclonal ASXL2 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 4750 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: ASXL2
2025-05-20 ASXL2抗體 Rabbit Polyclonal ASXL2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4750 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產品詳情

AliasesASXH2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ASXL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09336(ASXL2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09336(ASXL2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是關于ASXL2抗體的模擬參考文獻示例(注:實際文獻需通過學術數(shù)據(jù)庫查詢):

1. **文獻名稱**:*ASXL2 mutations promote myeloid transformation through loss of PRC2-mediated gene repression*

**作者**:Wang C. et al.

**摘要**:研究利用ASXL2抗體進行免疫沉淀和ChIP-seq分析,發(fā)現(xiàn)ASXL2突變通過破壞PRC2復合體的表觀遺傳調控功能,促進骨髓增生異常綜合征向白血病轉化。

2. **文獻名稱**:*ASXL2 interacts with cohesin to maintain chromatin integrity in hematopoietic stem cells*

**作者**:Li Z. et al.

**摘要**:通過ASXL2抗體的Western blot和免疫熒光實驗,揭示ASXL2與黏連蛋白復合體協(xié)同維持造血干細胞染色質穩(wěn)定性,缺失導致基因組不穩(wěn)定性。

3. **文獻名稱**:*Development and validation of a specific ASXL2 antibody for immunohistochemical analysis in solid tumors*

**作者**:Zhang Y. et al.

**摘要**:報道一種高特異性ASXL2抗體的開發(fā),并驗證其在乳腺癌和肺癌組織中的免疫組化應用,發(fā)現(xiàn)ASXL2表達與患者預后相關。

4. **文獻名稱**:*ASXL2 regulates lipid metabolism via PPARγ signaling in adipocytes*

**作者**:Kim H. et al.

**摘要**:利用ASXL2抗體敲低實驗,證明ASXL2通過調控PPARγ通路影響脂肪細胞分化及脂質代謝,為代謝性疾病提供新機制。

**建議**:通過PubMed或Google Scholar搜索“ASXL2 antibody”或“ASXL2 function”獲取最新文獻,關注其表觀遺傳調控及疾病機制研究。

       

背景信息

The ASXL2 antibody is a research tool used to detect and study the Additional Sex Combs-Like 2 (ASXL2) protein, a member of the ASXL family of chromatin-binding proteins. ASXL proteins (ASXL1-3) play roles in epigenetic regulation by modulating chromatin structure and gene expression through interactions with polycomb repressive complexes (PRC) and other transcriptional regulators. ASXL2. specifically, is involved in deubiquitination processes via its partnership with BAP1 (BRCA1-associated protein 1), influencing histone H2A ubiquitination and transcriptional activation or repression.

ASXL2 is implicated in normal hematopoiesis, embryonic development, and stem cell maintenance. Dysregulation or mutations in ASXL2 have been linked to cancers, including acute myeloid leukemia (AML), though its role is less characterized compared to ASXL1. ASXL2 antibodies are critical for investigating its expression patterns, subcellular localization, and functional interactions in both physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in cell lines or tissues. Researchers also utilize ASXL2 antibodies to explore its involvement in disease mechanisms, such as aberrant chromatin remodeling in malignancies. However, challenges remain in ensuring antibody specificity due to structural similarities among ASXL family members. Validation using knockout controls or siRNA knockdown is essential for reliable results. Ongoing studies aim to clarify ASXL2's dual roles as a tumor suppressor or oncogene, depending on cellular context.

       
關鍵字: ASXL2抗體;ASXL2;ASXL2 Antibody;

公司簡介

是一家科研、開發(fā)、生產和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,蛋白組學,細胞生物學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

ASXL2抗體—艾普蒂相關廠家報價

產品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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