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USP3抗體,Rabbit Polyclonal USP3 Antibody
  • USP3抗體,Rabbit Polyclonal USP3 Antibody
  • USP3抗體,Rabbit Polyclonal USP3 Antibody
  • USP3抗體,Rabbit Polyclonal USP3 Antibody

USP3抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
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產(chǎn)品詳情

中文名稱:USP3抗體英文名稱:Rabbit Polyclonal USP3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4746 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): USP3
2025-05-20 USP3抗體 Rabbit Polyclonal USP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4746 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesUBP; SIH003
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human USP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09329(USP3 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09329(USP3 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于USP3抗體的3篇代表性文獻(xiàn)的簡(jiǎn)要信息:

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1. **文獻(xiàn)名稱**:*USP3 regulates genome integrity and cancer development through deubiquitinating RPA*

**作者**:Nicassio, F. et al.

**摘要**:該研究揭示了USP3通過去泛素化復(fù)制蛋白A(RPA)在DNA損傷修復(fù)中的作用,利用特異性USP3抗體驗(yàn)證其在細(xì)胞核內(nèi)的定位,并證明其缺陷導(dǎo)致基因組不穩(wěn)定性和腫瘤易感性增加。

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2. **文獻(xiàn)名稱**:*The deubiquitinating enzyme USP3 stabilizes Aurora B to promote progression of mitosis*

**作者**:Zhu, Y. et al.

**摘要**:研究發(fā)現(xiàn)USP3通過穩(wěn)定Aurora B激酶調(diào)控有絲分裂進(jìn)程,實(shí)驗(yàn)中使用USP3抗體進(jìn)行免疫共沉淀(Co-IP)和Western blot分析,證實(shí)其與Aurora B的相互作用及功能關(guān)聯(lián)。

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3. **文獻(xiàn)名稱**:*USP3 modulates the chromatin status of homologous recombination repair genes through histone H2B deubiquitination*

**作者**:Zhang, L. et al.

**摘要**:該文獻(xiàn)提出USP3通過去泛素化組蛋白H2B調(diào)控染色質(zhì)可及性,促進(jìn)同源重組修復(fù)。研究利用USP3抗體進(jìn)行ChIP-seq分析,揭示了其在表觀遺傳調(diào)控中的新機(jī)制。

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以上文獻(xiàn)均通過USP3抗體進(jìn)行蛋白功能驗(yàn)證,涵蓋其在DNA修復(fù)、細(xì)胞周期及表觀遺傳中的關(guān)鍵作用。如需具體DOI或期刊信息,可進(jìn)一步補(bǔ)充檢索關(guān)鍵詞(如年份或期刊名稱)。

       

背景信息

The USP3 antibody targets ubiquitin-specific protease 3 (USP3), a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. USP3 plays a critical role in maintaining genomic stability by regulating DNA repair, chromatin remodeling, and cell cycle progression. It catalyzes the removal of ubiquitin chains from substrates, counteracting ubiquitin-mediated signaling. Research highlights its involvement in modulating key pathways, including the DNA damage response (DDR) via interactions with proteins like γH2AX and RAD51. as well as regulating NF-κB signaling by deubiquitinating TRAF proteins. USP3 is also implicated in cancer, where its dysregulation may influence tumor progression, metastasis, and chemoresistance.

Antibodies against USP3 are widely used in research to study its expression, localization, and molecular functions. They enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore USP3’s role in cellular processes and disease contexts. Studies using USP3 antibodies have revealed its nuclear localization and overexpression in certain cancers, suggesting its potential as a therapeutic target. Recent work also links USP3 to viral infection responses and immune regulation. However, challenges remain in fully characterizing its substrate specificity and context-dependent roles. Commercially available USP3 antibodies vary in specificity, requiring validation via knockout controls to ensure reliability in experimental settings.

       
關(guān)鍵字: USP3抗體;USP3;USP3 Antibody;

公司簡(jiǎn)介

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主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
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  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

USP3抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-02
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價(jià)
VIP4年
廣州瓏瑩生物科技有限公司
2025-07-24
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