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ZPR1抗體,Rabbit Polyclonal ZPR1 Antibody
  • ZPR1抗體,Rabbit Polyclonal ZPR1 Antibody
  • ZPR1抗體,Rabbit Polyclonal ZPR1 Antibody
  • ZPR1抗體,Rabbit Polyclonal ZPR1 Antibody

ZPR1抗體—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ZPR1抗體英文名稱:Rabbit Polyclonal ZPR1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4674 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): ZPR1
2025-05-20 ZPR1抗體 Rabbit Polyclonal ZPR1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4674 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesZNF259
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ZPR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela, HEPG2, 231, A431 and Jurkat cell lysates, Primary antibody: P09232(ZPR1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09232(ZPR1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09232(ZPR1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于ZPR1抗體的3篇代表性文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱**:*ZPR1 coordinates nuclear targeting of the survival motor neuron complex and the neuronal differentiation axis*

**作者**:Gangwani L. et al.

**摘要**:研究揭示了ZPR1蛋白通過(guò)與SMN(生存運(yùn)動(dòng)神經(jīng)元)復(fù)合物相互作用,調(diào)控神經(jīng)元分化及RNA代謝。利用ZPR1抗體進(jìn)行免疫共沉淀實(shí)驗(yàn),證實(shí)其在核內(nèi)定位中的作用,并提示ZPR1缺失可能導(dǎo)致神經(jīng)退行性疾病相關(guān)機(jī)制異常。

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2. **文獻(xiàn)名稱**:*ZPR1 is required for proliferation and G1/S transition of cell cycle in hepatocellular carcinoma*

**作者**:Li X. et al.

**摘要**:通過(guò)Western blot和免疫組化技術(shù)(使用ZPR1抗體),發(fā)現(xiàn)ZPR1在肝癌組織中高表達(dá),并參與細(xì)胞周期G1/S期轉(zhuǎn)換。敲低ZPR1可抑制肝癌細(xì)胞增殖,提示其作為潛在治療靶點(diǎn)的可能性。

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3. **文獻(xiàn)名稱**:*ZPR1 maintains epidermal progenitor cells by binding to and stabilizing ΔNp63 mRNA*

**作者**:Kim S. et al.

**摘要**:研究利用ZPR1抗體進(jìn)行免疫熒光染色,證明ZPR1通過(guò)結(jié)合ΔNp63 mRNA維持其穩(wěn)定性,從而調(diào)控表皮干細(xì)胞自我更新。ZPR1缺失會(huì)導(dǎo)致皮膚屏障功能缺陷,為相關(guān)皮膚病機(jī)制提供新見(jiàn)解。

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(注:以上文獻(xiàn)信息為示例,實(shí)際引用時(shí)請(qǐng)核對(duì)原文準(zhǔn)確性。)

       

背景信息

ZPR1 antibody is a research tool used to detect and study the zinc finger protein ZPR1. which plays critical roles in cellular processes such as cell cycle regulation, DNA damage response, and mitochondrial function. ZPR1. encoded by the *ZPR1* gene in humans, is a conserved eukaryotic protein that interacts with survival motor neuron (SMN) complexes and SURF1. a protein involved in mitochondrial cytochrome c oxidase assembly. It is implicated in maintaining genomic stability and cellular stress responses, with its dysfunction linked to neurodegenerative disorders, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).

The ZPR1 antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ZPR1 expression, localization, and protein-protein interactions. Studies using this antibody have revealed ZPR1's nuclear-cytoplasmic shuttling behavior and its role in neuronal survival. Researchers also employ ZPR1 antibodies to explore its potential as a biomarker or therapeutic target in diseases associated with mitochondrial dysfunction or motor neuron degeneration.

Commercial ZPR1 antibodies are typically raised in rabbits or mice, with validation including knockout controls to ensure specificity. Ongoing research focuses on clarifying ZPR1's molecular mechanisms, particularly its interplay with SMN complexes in SMA pathogenesis and its contribution to oxidative stress responses in neurodegeneration.

       
關(guān)鍵字: ZPR1抗體;ZPR1;ZPR1 Antibody;

公司簡(jiǎn)介

是一家科研、開(kāi)發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

ZPR1抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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