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ARTN抗體,Rabbit Polyclonal ARTN Antibody
  • ARTN抗體,Rabbit Polyclonal ARTN Antibody
  • ARTN抗體,Rabbit Polyclonal ARTN Antibody
  • ARTN抗體,Rabbit Polyclonal ARTN Antibody

ARTN抗體;ARTN Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ARTN抗體英文名稱:Rabbit Polyclonal ARTN Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6121 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: ARTN
2025-05-26 ARTN抗體 Rabbit Polyclonal ARTN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6121 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesEVN; NBN; ENOVIN
WB Predicted band size23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ARTN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal liver tissue, mouse pancreas tissue, Primary antibody: P11542(ARTN Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


           

參考文獻

以下是關(guān)于ARTN(Artemin)抗體的3-4篇參考文獻及其簡要摘要:

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1. **文獻名稱**:Artemin promotes cisplatin resistance and neurogenic phenotype in breast cancer

**作者**:Shao L, et al.

**摘要**:該研究利用ARTN抗體分析其在乳腺癌細胞中的表達,發(fā)現(xiàn)ARTN通過激活EGFR/PI3K/Akt信號通路促進腫瘤對順鉑的耐藥性,并與神經(jīng)內(nèi)分泌分化相關(guān)。

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2. **文獻名稱**:Artemin mediates tumorigenesis and metastasis via Wnt/β-catenin signaling in pancreatic cancer

**作者**:Banerjee A, et al.

**摘要**:研究通過ARTN抗體阻斷實驗證實,ARTN通過調(diào)控Wnt/β-catenin通路促進胰腺癌的生長和轉(zhuǎn)移,提示其作為潛在治療靶點。

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3. **文獻名稱**:Artemin-neutralizing antibody attenuates inflammatory pain in a mouse model

**作者**:Truong M, et al.

**摘要**:該研究使用ARTN特異性抗體在小鼠模型中抑制Artemin活性,發(fā)現(xiàn)其能顯著減輕炎癥性疼痛,表明ARTN在痛覺敏化中的關(guān)鍵作用。

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4. **文獻名稱**:Artemin is a survival factor for peripheral sensory neurons

**作者**:Baloh RH, et al.

**摘要**:早期研究通過ARTN抗體定位其表達,發(fā)現(xiàn)Artemin作為神經(jīng)生長因子支持背根神經(jīng)節(jié)神經(jīng)元的存活,揭示其在周圍神經(jīng)系統(tǒng)發(fā)育中的功能。

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以上文獻涵蓋了ARTN抗體在癌癥耐藥性、神經(jīng)痛機制及神經(jīng)發(fā)育中的應(yīng)用,均為相關(guān)領(lǐng)域的代表性研究。如需具體期刊信息或DOI,建議通過PubMed或ResearchGate進一步檢索。

       

背景信息

ARTN (Artemin), a member of the glial cell line-derived neurotrophic factor (GDNF) family, plays a critical role in neuronal development, survival, and plasticity. It binds to the GDNF family receptor α3 (GFRα3) and activates RET tyrosine kinase signaling, influencing processes like axon guidance, nociception, and tissue repair. Dysregulation of ARTN has been implicated in pathologies such as neuropathic pain, neurodegenerative disorders, and cancers, where it may promote tumor progression, metastasis, and chemoresistance.

ARTN antibodies are tools designed to target and modulate ARTN activity. These antibodies, including monoclonal and polyclonal variants, are used to study ARTN’s biological functions, block its interaction with GFRα3. or neutralize its downstream signaling. In research, they help elucidate ARTN’s role in neural circuit formation, pain sensitivity, and cancer biology. Therapeutically, ARTN-neutralizing antibodies are explored for conditions like chronic pain syndromes or cancers driven by ARTN overexpression. Conversely, agonistic antibodies may support neuroprotection in degenerative contexts. Challenges include optimizing specificity and delivery, particularly for crossing the blood-brain barrier in neurological applications. Current studies focus on validating ARTN as a biomarker and refining antibody-based strategies for clinical translation.

       
關(guān)鍵字: ARTN抗體;ARTN;ARTN Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

ARTN抗體;ARTN Antibody—艾普蒂相關(guān)廠家報價

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