The Aurora kinase C (AURKC) antibody is a research tool targeting AURKC, a member of the Aurora kinase family involved in regulating cell division. AURKC, primarily expressed in germ cells, plays a critical role in meiosis, particularly during spermatogenesis and oocyte maturation. Unlike Aurora kinases A and B, which function in mitosis, AURKC is specialized for gametogenesis, ensuring proper chromosome segregation and cytokinesis. Dysregulation of AURKC is linked to reproductive disorders, such as infertility, and has been implicated in certain cancers.
AURKC antibodies are used to detect and study the protein’s expression, localization, and function in cellular models. These antibodies are typically validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers employ them to investigate AURKC’s role in germ cell development, its interaction with other meiotic proteins, and its potential as a biomarker or therapeutic target. Polyclonal and monoclonal variants exist, with specificity and sensitivity varying based on epitope recognition.
Given its tissue-specific expression, AURKC antibodies are particularly valuable in reproductive biology and oncology studies. However, cross-reactivity with other Aurora kinases (e.g., AURKB) is a common challenge, necessitating rigorous validation. Overall, AURKC antibodies serve as essential tools for unraveling the molecular mechanisms of gametogenesis and exploring disease-associated pathways.