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     Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: P11460(APBA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

The APBA1 antibody targets the amyloid beta precursor protein-binding family A member 1 (APBA1), also known as Mint1 or X11α. APBA1 is a neuronal adaptor protein encoded by the APBA1 gene, primarily expressed in the brain. It belongs to the X11 protein family and contains a phosphotyrosine-binding (PTB) domain, enabling interactions with the cytoplasmic domain of amyloid precursor protein (APP). This interaction plays a critical role in regulating APP processing, influencing the production of amyloid-beta (Aβ) peptides implicated in Alzheimer’s disease pathogenesis. APBA1 also participates in synaptic vesicle trafficking, neurotransmitter release, and neuronal signal transduction.

APBA1 antibodies are widely used in neuroscience research to study protein localization, expression levels, and molecular mechanisms in neurodegenerative disorders. They help detect APBA1 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of APBA1 has been linked to altered APP metabolism, synaptic dysfunction, and cognitive deficits. Additionally, APBA1 interacts with other synaptic proteins, such as CASK and Munc18. suggesting broader roles in synaptic plasticity. Research using APBA1 antibodies contributes to understanding its potential as a therapeutic target or biomarker in Alzheimer’s disease and related dementias.