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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human prostate tissue lysate, Primary antibody: P11427(ADAMTS16 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11427(ADAMTS16 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

ADAMTS16 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 16) is a member of the ADAMTS family of secreted proteases, which play critical roles in extracellular matrix (ECM) remodeling, tissue development, and disease progression. This enzyme contains conserved domains, including a propeptide, metalloproteinase, disintegrin-like, and thrombospondin motifs, enabling interactions with ECM components and cellular signaling pathways. ADAMTS16 is implicated in diverse physiological processes, such as organogenesis, angiogenesis, and connective tissue homeostasis, as well as pathological conditions like cancer, cardiovascular disorders, and genetic syndromes.

Antibodies targeting ADAMTS16 are essential tools for studying its expression, localization, and function. These antibodies, often developed in rabbits or mice using immunogenic peptide regions of the protein, enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research applications include investigating ADAMTS16's role in tumor progression (e.g., regulating cell adhesion or metastasis) or its association with hypertension and kidney development. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing.

Despite progress, ADAMTS16's full mechanistic landscape remains understudied. Reliable antibodies are crucial for elucidating its tissue-specific roles, post-translational modifications, and potential as a therapeutic target or biomarker in diseases linked to ECM dysregulation.