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ITGB7抗體,Mouse Monoclonal ITGB7 Antibody
  • ITGB7抗體,Mouse Monoclonal ITGB7 Antibody
  • ITGB7抗體,Mouse Monoclonal ITGB7 Antibody
  • ITGB7抗體,Mouse Monoclonal ITGB7 Antibody

ITGB7抗體;ITGB7 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ITGB7抗體英文名稱:Mouse Monoclonal ITGB7 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1459 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): ITGB7
2025-05-25 ITGB7抗體 Mouse Monoclonal ITGB7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1459 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/50 - 1/200 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

Entrez GeneID3695
clone4C5D2
WB Predicted band size86.9kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ITGB7 (AA: 20-174) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using ITGB7 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of HL-60 cells using ITGB7 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using ITGB7 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using ITGB7 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于ITGB7抗體的3篇代表性文獻(xiàn),按作者、標(biāo)題和摘要內(nèi)容簡要概括:

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1. **作者**:Cheroutre, H. & Lambolez, F.

**標(biāo)題**:Targeting integrin α4β7 for the treatment of inflammatory bowel disease

**摘要**:研究探討了靶向整合素α4β7(含ITGB7亞基)的抗體在炎癥性腸病(IBD)治療中的作用,通過阻斷淋巴細(xì)胞向腸道遷移,顯著減輕小鼠結(jié)腸炎模型的炎癥反應(yīng)。

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2. **作者**:Kato, K., et al.

**標(biāo)題**:Anti-β7 integrin antibody inhibits tumor metastasis by disrupting cancer cell adhesion to endothelial cells

**摘要**:發(fā)現(xiàn)抗ITGB7抗體通過阻斷腫瘤細(xì)胞與血管內(nèi)皮細(xì)胞的黏附,抑制黑色素瘤小鼠模型中的轉(zhuǎn)移,表明其在癌癥免疫治療中的潛在應(yīng)用。

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3. **作者**:Berlin, C., et al.

**標(biāo)題**:α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

**摘要**:經(jīng)典研究闡明了ITGB7與α4組成的整合素α4β7在介導(dǎo)淋巴細(xì)胞歸巢至腸道黏膜的機(jī)制,為后續(xù)抗體藥物的開發(fā)奠定理論基礎(chǔ)。

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如需更多文獻(xiàn)或具體領(lǐng)域(如臨床實(shí)驗(yàn)),可進(jìn)一步調(diào)整關(guān)鍵詞檢索。

       

背景信息

The ITGB7 antibody targets the integrin beta-7 subunit (β7), a cell surface receptor critical for immune cell trafficking and adhesion. Integrins are heterodimeric proteins composed of α and β subunits. β7 pairs with α4 or αE subunits, forming α4β7 and αEβ7 integrins. α4β7 mediates lymphocyte homing to gut-associated lymphoid tissues (GALT) by binding to mucosal addressin cell adhesion molecule-1 (MAdCAM-1), while αEβ7 facilitates retention of intraepithelial lymphocytes via interactions with E-cadherin.

ITGB7 is predominantly expressed on immune cells, including T and B lymphocytes, particularly those localized to mucosal surfaces. Its role in gut-specific immune responses has made it a focus in studying inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis. Therapeutic antibodies blocking α4β7 (e.g., vedolizumab) are used to dampen intestinal inflammation by inhibiting leukocyte migration.

Research also links ITGB7 to cancer progression, as tumor cells may exploit β7 integrins for metastasis. Antibodies against ITGB7 serve as tools to study these mechanisms or as potential therapeutics. However, their clinical application beyond IBD remains exploratory. Understanding ITGB7’s dual roles in immunity and pathology underscores its importance as a biomarker and therapeutic target in mucosal immunity and oncology.

       
關(guān)鍵字: ITGB7抗體;ITGB7;ITGB7 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

ITGB7抗體;ITGB7 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
武漢佰樂博生物技術(shù)有限公司
2025-08-01
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
湖北艾普蒂生物工程有限公司
2024-02-21
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