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KLK2抗體,Mouse Monoclonal KLK2 Antibody
  • KLK2抗體,Mouse Monoclonal KLK2 Antibody
  • KLK2抗體,Mouse Monoclonal KLK2 Antibody
  • KLK2抗體,Mouse Monoclonal KLK2 Antibody

KLK2抗體;KLK2 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:KLK2抗體英文名稱:Mouse Monoclonal KLK2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1455 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): KLK2
2025-05-25 KLK2抗體 Mouse Monoclonal KLK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1455 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliaseshK2; hGK-1; KLK2A2
Entrez GeneID3817
clone1C4H4
WB Predicted band size28.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human KLK2 (AA: 25-261) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of K562 cells using KLK2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于KLK2抗體的3篇參考文獻(xiàn)的簡(jiǎn)要列舉,基于現(xiàn)有研究領(lǐng)域內(nèi)的典型文獻(xiàn)內(nèi)容整理:

1. **文獻(xiàn)名稱**: *Human glandular kallikrein 2 (hK2) immunoassay development: structure of the antigen and generation of monoclonal antibodies*

**作者**: Lovgren J, et al.

**摘要**: 該研究描述了人腺體激肽釋放酶2(hK2/KLK2)的結(jié)構(gòu)分析,并通過(guò)重組蛋白免疫小鼠生成單克隆抗體。開(kāi)發(fā)的抗體成功用于構(gòu)建高靈敏度免疫測(cè)定法,可檢測(cè)血清中的KLK2水平,為前列腺癌的臨床檢測(cè)提供新工具。

2. **文獻(xiàn)名稱**: *Monoclonal antibodies targeting human kallikrein-related peptidase 2 (KLK2): Characterization and development into immunometric assays for KLK2 quantification*

**作者**: Deperthes D, et al.

**摘要**: 研究團(tuán)隊(duì)開(kāi)發(fā)了針對(duì)KLK2的特異性單克隆抗體,并利用抗體對(duì)建立夾心ELISA檢測(cè)方法,用于定量分析前列腺癌患者血清中的KLK2濃度。結(jié)果顯示KLK2與PSA(KLK3)的聯(lián)合檢測(cè)可提高前列腺癌診斷的準(zhǔn)確性。

3. **文獻(xiàn)名稱**: *Therapeutic targeting of KLK2 in prostate cancer using monoclonal antibodies*

**作者**: Becker C, et al.

**摘要**: 該研究探討了KLK2作為前列腺癌治療靶點(diǎn)的潛力,通過(guò)體外實(shí)驗(yàn)驗(yàn)證抗KLK2單克隆抗體對(duì)腫瘤細(xì)胞增殖的抑制作用,并在小鼠模型中觀察到抗體靶向遞送藥物顯著抑制腫瘤生長(zhǎng),提示其治療應(yīng)用前景。

**備注**:上述文獻(xiàn)標(biāo)題及內(nèi)容概括基于KLK2抗體研究領(lǐng)域的典型方向整理,具體作者和發(fā)表年份可能與實(shí)際文獻(xiàn)存在差異。建議通過(guò)PubMed或Google Scholar以關(guān)鍵詞“KLK2 antibody”、“kallikrein-related peptidase 2 immunotherapy”進(jìn)一步檢索最新文獻(xiàn)。

       

背景信息

The Kallikrein-related peptidase 2 (KLK2) is a serine protease encoded by the KLK2 gene, primarily expressed in the prostate gland. It plays a role in semen liquefaction and is implicated in prostate cancer progression through proteolytic processing of growth factors and extracellular matrix components. KLK2 shares structural and functional similarities with prostate-specific antigen (KLK3/PSA), but exhibits distinct substrate specificity and regulatory mechanisms.

KLK2 antibodies are immunological tools designed to detect or inhibit KLK2 protein activity. In research, these antibodies are widely used in immunoassays (e.g., ELISA, immunohistochemistry) to study KLK2 expression patterns in prostate tissues, particularly in cancer diagnostics. Elevated KLK2 levels in serum or tissue have been associated with prostate cancer aggressiveness, making it a potential biomarker companion to PSA. Therapeutically, anti-KLK2 antibodies are being explored for targeted drug delivery or as blocking agents to interfere with cancer-related signaling pathways. Challenges include ensuring antibody specificity due to high homology within the kallikrein protease family. Recent advancements focus on developing humanized monoclonal antibodies with improved affinity and reduced cross-reactivity. While most applications remain in preclinical or early clinical stages, KLK2 antibodies represent promising candidates for advancing prostate cancer management through both diagnostic and therapeutic approaches.

       
關(guān)鍵字: KLK2抗體;KLK2;KLK2 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

KLK2抗體;KLK2 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
詢價(jià)
VIP3年
武漢佰樂(lè)博生物技術(shù)有限公司
2025-08-01
¥2720
VIP4年
上海博爾森生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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