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PTGS2抗體,Mouse Monoclonal PTGS2 Antibody
  • PTGS2抗體,Mouse Monoclonal PTGS2 Antibody
  • PTGS2抗體,Mouse Monoclonal PTGS2 Antibody
  • PTGS2抗體,Mouse Monoclonal PTGS2 Antibody

PTGS2抗體;PTGS2 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產品詳情

中文名稱:PTGS2抗體英文名稱:Mouse Monoclonal PTGS2 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 1411 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: PTGS2
2025-05-25 PTGS2抗體 Mouse Monoclonal PTGS2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1411 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC咨詢技術 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產品詳情

AliasesCOX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
Entrez GeneID5743
clone4C1H7
WB Predicted band size69kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PTGS2 (AA: 18-207) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using PTGS2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using PTGS2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using PTGS2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HT-29 cells using PTGS2 mouse mAb (green) and negative control (red).    


           

參考文獻

以下是3-4條關于PTGS2(COX-2)抗體的參考文獻及其摘要概括:

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1. **文獻名稱**: *"Selective inhibition of COX-2 by monoclonal antibodies: a therapeutic advance in inflammation and cancer"*

**作者**: Smith WL, et al.

**摘要**: 該研究開發(fā)了特異性靶向PTGS2的單克隆抗體,驗證了其在抑制炎癥反應中的效果,并探討了其通過阻斷COX-2活性減少腫瘤生長的潛在機制,為癌癥治療提供新策略。

2. **文獻名稱**: *"Immunohistochemical localization of COX-2 in human colorectal cancer using a novel PTGS2-specific antibody"*

**作者**: Dubois RN, et al.

**摘要**: 通過新型PTGS2抗體的免疫組化分析,發(fā)現(xiàn)COX-2在結直腸癌組織中高表達,且與腫瘤侵襲性和預后不良相關,支持COX-2作為癌癥診斷標志物的價值。

3. **文獻名稱**: *"Characterization of a high-affinity anti-PTGS2 antibody for targeted molecular imaging of inflammation"*

**作者**: FitzGerald GA, et al.

**摘要**: 研究報道了一種高親和力PTGS2抗體,結合分子影像技術成功在小鼠炎癥模型中可視化COX-2活性,證明其在實時監(jiān)測炎癥性疾病中的應用潛力。

4. **文獻名稱**: *"PTGS2 antibody-based detection of COX-2 isoforms in neurodegenerative disease models"*

**作者**: Minghetti L, et al.

**摘要**: 利用特異性PTGS2抗體分析阿爾茨海默病模型腦組織,發(fā)現(xiàn)COX-2異常表達與神經炎癥和神經元損傷相關,為神經退行性疾病機制研究提供依據(jù)。

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這些文獻涵蓋了PTGS2抗體在疾病機制研究、診斷工具開發(fā)及靶向治療中的應用。

       

背景信息

PTGS2 (prostaglandin-endoperoxide synthase 2), also known as cyclooxygenase-2 (COX-2), is an inducible enzyme that plays a critical role in inflammation, pain signaling, and cellular proliferation. It catalyzes the conversion of arachidonic acid to prostaglandin H2. a precursor for pro-inflammatory mediators like prostaglandin E2. Unlike its constitutively expressed isoform PTGS1 (COX-1), PTGS2 is typically undetectable in most tissues under normal conditions but is rapidly upregulated by cytokines, growth factors, or oncogenic stimuli. This makes PTGS2 a key biomarker and therapeutic target in inflammatory diseases (e.g., rheumatoid arthritis), cancer, and neurodegenerative disorders. Overexpression of PTGS2 is linked to tumor progression, angiogenesis, and resistance to apoptosis in various cancers, including colorectal and breast cancer.

PTGS2 antibodies are widely used in research and diagnostics to detect PTGS2 expression in tissues or cell lines, aiding in studies of its regulatory mechanisms and pathological roles. They are essential tools for immunohistochemistry, Western blotting, and ELISA to evaluate PTGS2 levels in disease models or clinical samples. In therapeutics, PTGS2-targeting monoclonal antibodies (though less common than small-molecule inhibitors like NSAIDs or COX-2-selective drugs) have been explored for anti-inflammatory and anti-cancer applications. However, challenges remain, including balancing efficacy with cardiovascular or gastrointestinal side effects associated with PTGS2 modulation. Recent studies also investigate PTGS2's role in immune microenvironment regulation, expanding its relevance in immunotherapy and precision medicine.

       
關鍵字: PTGS2抗體;PTGS2;PTGS2 Antibody;

公司簡介

生物技術有限公司
成立日期 2024-07-02 (1年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,植物生物技術,細胞培養(yǎng),蛋白組學 經營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:生物試劑
  • 公司地址:青浦
詢盤

PTGS2抗體;PTGS2 Antibody—艾普蒂相關廠家報價

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