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Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody
  • Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody
  • Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody
  • Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody

GOLGA2抗體;GOLGA2 Antibody—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mouse Monoclonal GOLGA2 Antibody英文名稱:Mouse Monoclonal GOLGA2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1407 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): GOLGA2
2025-05-25 Mouse Monoclonal GOLGA2 Antibody Mouse Monoclonal GOLGA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1407 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/50 - 1/200 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGM130
Entrez GeneID2801
clone2D3D12
WB Predicted band size113kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GOLGA2 (AA: 1-205) expressed in HEK293-6e cells supernatant.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using GOLGA2 mouse mAb against HepG2 (1), Hela (2), K562 (3), and HEK293 (4) cell lysate.    


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       Immunofluorescence analysis of Hela cells using GOLGA2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using GOLGA2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using GOLGA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using GOLGA2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下為3篇與GOLGA2抗體相關(guān)的研究文獻(xiàn)示例:

1. **文獻(xiàn)名稱**:Golgin-84 is required for Golgi structure formation during mitosis

**作者**:Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M

**摘要**:該研究利用GOLGA2(GM130)抗體探究高爾基體基質(zhì)蛋白(包括GM130和golgin-84)在細(xì)胞分裂過程中維持高爾基體碎片化結(jié)構(gòu)的作用,發(fā)現(xiàn)這些蛋白對(duì)高爾基體重新組裝至關(guān)重要。

2. **文獻(xiàn)名稱**:Expression of Golgi protein GOLGA2 in colorectal cancer progression and its clinical significance

**作者**:Lin Y, Xu J, Lu H, et al.

**摘要**:通過免疫組化分析GOLGA2在結(jié)直腸癌組織中的表達(dá),發(fā)現(xiàn)其高表達(dá)與腫瘤轉(zhuǎn)移和不良預(yù)后相關(guān),提示GOLGA2可能作為癌癥生物標(biāo)志物。

3. **文獻(xiàn)名稱**:Herpes simplex virus 1 cytoplasmic envelopment requires functional Golgi recruitment by its membrane protein US10

**作者**:Metrick CM, Koenigsberg AL, Heldwein EE

**摘要**:研究利用GOLGA2抗體標(biāo)記高爾基體,發(fā)現(xiàn)皰疹病毒US10蛋白通過干擾高爾基體結(jié)構(gòu)促進(jìn)病毒包膜形成,揭示病毒劫持宿主細(xì)胞器的機(jī)制。

注:以上文獻(xiàn)為示例,實(shí)際引用時(shí)建議通過PubMed等數(shù)據(jù)庫核對(duì)最新研究。GOLGA2抗體常用于研究高爾基體結(jié)構(gòu)、癌癥及病毒感染機(jī)制。

       

背景信息

GOLGA2 antibodies are primarily associated with research on the Golgi apparatus and autoimmune disorders. GOLGA2. also known as Golgin A2 or GM130. is a peripheral membrane protein located on the Golgi stack. It plays a critical role in maintaining Golgi structure, vesicle trafficking, and glycosylation processes. Antibodies targeting GOLGA2 are widely used as markers in immunofluorescence and immunoblotting to visualize the Golgi complex in cellular studies.

In clinical contexts, GOLGA2 autoantibodies have been identified in certain autoimmune conditions. Notably, they are detected in a subset of patients with paraneoplastic syndromes, particularly those with cancer-associated retinopathy (CAR) or melanoma-associated retinopathy (MAR). These autoantibodies may arise due to molecular mimicry between tumor antigens and retinal proteins, triggering immune cross-reactivity. Additionally, GOLGA2 antibodies have been reported in rare cases of autoimmune hepatitis and connective tissue disorders, though their pathogenicity remains unclear.

Research also links GOLGA2 dysregulation to cancer progression. Overexpression of GOLGA2 is observed in malignancies like hepatocellular carcinoma and colorectal cancer, potentially influencing cell proliferation and metastasis. However, most studies focus on its role as an autoantigen or structural protein rather than a therapeutic target. Continued investigation aims to clarify its diagnostic utility and mechanistic contributions to disease pathways.

       
關(guān)鍵字: GOLGA2抗體;GOLGA2;GOLGA2 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (1年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

GOLGA2抗體;GOLGA2 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
碧云天生物技術(shù)有限公司
2025-05-28
¥1280
VIP1年
湖北艾普蒂生物工程有限公司
2025-05-30
¥4800
科博瑞(武漢)生物科技有限公司
2025-04-15
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