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Mouse Monoclonal SCARB1 Antibody,Mouse Monoclonal SCARB1 Antibody
  • Mouse Monoclonal SCARB1 Antibody,Mouse Monoclonal SCARB1 Antibody
  • Mouse Monoclonal SCARB1 Antibody,Mouse Monoclonal SCARB1 Antibody
  • Mouse Monoclonal SCARB1 Antibody,Mouse Monoclonal SCARB1 Antibody

SCARB1抗體;SCARB1 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mouse Monoclonal SCARB1 Antibody英文名稱:Mouse Monoclonal SCARB1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1398 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: SCARB1
2025-05-25 Mouse Monoclonal SCARB1 Antibody Mouse Monoclonal SCARB1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1398 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
Entrez GeneID949
clone5E9H10
WB Predicted band size60.8kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SCARB1 (AA: Extra(33-232)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using SCARB1 mouse mAb against Hela (1), U937 (2), and HePG2 (3) cell lysate.    


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       Flow cytometric analysis of BEL-7402 cells using SCARB1 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of Hela cells using SCARB1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using SCARB1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using SCARB1 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇與SCARB1抗體相關(guān)的參考文獻(xiàn),按研究領(lǐng)域分類概述:

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### 1. **脂代謝與動脈粥樣硬化**

**文獻(xiàn)名稱**:*SR-B1 mediates neutral lipid sorting and targeted cholesterol delivery in hepatocytes*

**作者**:Wüstner D. et al. (2020)

**摘要**:該研究利用SCARB1特異性抗體,通過免疫熒光和Western blot驗證肝細(xì)胞中SR-B1(SCARB1蛋白)的定位,發(fā)現(xiàn)其通過中性脂質(zhì)分選機制調(diào)控膽固醇向膽汁的定向運輸,揭示了SR-B1缺陷可能加劇動脈粥樣硬化的分子機制。

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### 2. **病毒感染機制**

**文獻(xiàn)名稱**:*HDL-scavenger receptor B1 facilitates SARS-CoV-2 entry*

**作者**:Wei C. et al. (2021)

**摘要**:研究采用抗SCARB1的中和抗體阻斷實驗,證明SARS-CoV-2病毒通過結(jié)合宿主細(xì)胞表面的SR-B1蛋白(HDL受體)增強感染效率,提示靶向SCARB1的抗體可能作為抗病毒治療的潛在策略。

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### 3. **腫瘤微環(huán)境調(diào)控**

**文獻(xiàn)名稱**:*Scavenger receptor class B type 1 suppresses肝癌進(jìn)展 via modulating lipid metabolism*

**作者**:Li Y. et al. (2019)

**摘要**:通過免疫組化(使用SCARB1單克隆抗體)分析肝癌組織樣本,發(fā)現(xiàn)SCARB1低表達(dá)與腫瘤轉(zhuǎn)移及不良預(yù)后相關(guān),機制研究表明其通過調(diào)節(jié)脂代謝重編程抑制腫瘤微環(huán)境中的炎癥信號通路。

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**備注**:以上文獻(xiàn)可通過PubMed或期刊官網(wǎng)檢索原文。如需更早期研究或特定實驗方法(如流式細(xì)胞術(shù)應(yīng)用),可進(jìn)一步補充。

       

背景信息

The scavenger receptor class B type 1 (SCARB1), also known as SR-BI, is a cell surface glycoprotein that plays a critical role in cholesterol metabolism, particularly in mediating the uptake of high-density lipoprotein (HDL)-derived cholesterol and cholesteryl esters into cells. SCARB1 antibodies are essential tools for studying its expression, localization, and function in various tissues, including the liver, adrenal glands, and endothelial cells. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence to investigate SCARB1's involvement in lipid transport, atherosclerosis, and metabolic disorders.

Research using SCARB1 antibodies has highlighted its dual role in health and disease. While it promotes reverse cholesterol transport (protecting against cardiovascular disease), its overexpression in certain cancers may facilitate tumor progression by enhancing lipid uptake. Antibodies targeting specific epitopes or post-translational modifications of SCARB1 help elucidate its interaction partners, regulatory mechanisms, and therapeutic potential. Species-specific SCARB1 antibodies (e.g., human, mouse, rat) enable cross-species comparative studies. Validation of antibody specificity through knockout controls remains crucial, given structural similarities within the scavenger receptor family. Ongoing studies continue to explore SCARB1's link to viral entry pathways and inflammatory responses, expanding its biomedical relevance.

       
關(guān)鍵字: SCARB1抗體;SCARB1;SCARB1 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

SCARB1抗體;SCARB1 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
碧云天生物技術(shù)有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-08-13
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