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Mouse Monoclonal ASGR2 Antibody,Mouse Monoclonal ASGR2 Antibody
  • Mouse Monoclonal ASGR2 Antibody,Mouse Monoclonal ASGR2 Antibody
  • Mouse Monoclonal ASGR2 Antibody,Mouse Monoclonal ASGR2 Antibody
  • Mouse Monoclonal ASGR2 Antibody,Mouse Monoclonal ASGR2 Antibody

ASGR2抗體;ASGR2 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mouse Monoclonal ASGR2 Antibody英文名稱:Mouse Monoclonal ASGR2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1290 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): ASGR2
2025-05-25 Mouse Monoclonal ASGR2 Antibody Mouse Monoclonal ASGR2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1290 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2
Entrez GeneID433
clone2C6D11
WB Predicted band size35kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ASGR2 (AA: 80-311) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using ASGR2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using ASGR2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using ASGR2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇關(guān)于ASGR2抗體的研究文獻(xiàn)摘要(文獻(xiàn)標(biāo)題和作者為虛構(gòu)示例,供參考):

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1. **"Targeting ASGR2 with monoclonal antibody suppresses hepatocellular carcinoma progression"**

*作者:Li, X. et al. (2022)*

摘要:研究開(kāi)發(fā)了一種靶向ASGR2的單克隆抗體,通過(guò)阻斷ASGR2介導(dǎo)的細(xì)胞信號(hào)通路,顯著抑制肝癌細(xì)胞增殖和遷移,并在小鼠模型中降低腫瘤負(fù)荷。

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2. **"ASGR2-directed CAR-T cells exhibit potent anti-tumor activity in solid tumors"**

*作者:Wang, Y. et al. (2021)*

摘要:首次報(bào)道了基于ASGR2抗體的CAR-T細(xì)胞療法,證明其在表達(dá)ASGR2的結(jié)直腸癌和胃癌模型中能高效識(shí)別并清除腫瘤細(xì)胞,為實(shí)體瘤治療提供新策略。

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3. **"ASGR2 as a biomarker for liver fibrosis: Diagnostic potential of a novel polyclonal antibody"**

*作者:Kim, S. et al. (2020)*

摘要:開(kāi)發(fā)了針對(duì)ASGR2的多克隆抗體,驗(yàn)證了其在肝纖維化患者血清和組織中的高表達(dá),提示ASGR2可作為肝纖維化診斷和分期的潛在生物標(biāo)志物。

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*注:以上文獻(xiàn)為示例,實(shí)際研究中請(qǐng)通過(guò)PubMed或Web of Science檢索真實(shí)文獻(xiàn)。如需具體文章,可進(jìn)一步提供數(shù)據(jù)庫(kù)訪問(wèn)權(quán)限協(xié)助查詢。*

       

背景信息

The asialoglycoprotein receptor 2 (ASGR2) is a transmembrane protein belonging to the C-type lectin family, primarily expressed on hepatocytes. It forms heterodimers with ASGR1 to mediate the clearance of desialylated glycoproteins by recognizing terminal galactose or N-acetylgalactosamine residues. ASGR2 plays a critical role in maintaining serum glycoprotein homeostasis and has been implicated in liver physiology, including cholesterol metabolism and viral entry mechanisms (e.g., hepatitis B virus).

ASGR2 antibodies are tools developed to study the receptor's expression, function, and interaction partners. In research, they are used in applications such as immunohistochemistry, Western blotting, and flow cytometry to investigate ASGR2 localization and dynamics in liver diseases, including hepatocellular carcinoma and metabolic disorders. Therapeutically, ASGR2 has emerged as a potential target for liver-directed therapies. Antibody-based approaches, such as antibody-drug conjugates or bispecific antibodies, are being explored to deliver cytotoxic agents or modulate receptor activity in cancers and hypercholesterolemia.

Recent studies highlight ASGR2's involvement in tumor progression and immune evasion, driving interest in its diagnostic and prognostic value. However, challenges remain in optimizing antibody specificity and minimizing off-target effects due to structural similarities with other lectins. Ongoing research aims to leverage ASGR2 antibodies for precision medicine in hepatobiliary pathologies.

       
關(guān)鍵字: ASGR2抗體;ASGR2;ASGR2 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤(pán)

ASGR2抗體;ASGR2 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
碧云天生物技術(shù)有限公司
2025-08-02
¥4800
科博瑞(武漢)生物科技有限公司
2025-04-15
¥1640.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
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