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SPCS2抗體,Rabbit Polyclonal SPCS2 Antibody
  • SPCS2抗體,Rabbit Polyclonal SPCS2 Antibody
  • SPCS2抗體,Rabbit Polyclonal SPCS2 Antibody
  • SPCS2抗體,Rabbit Polyclonal SPCS2 Antibody

SPCS2抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SPCS2抗體英文名稱:Rabbit Polyclonal SPCS2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4595 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: SPCS2
2025-05-19 SPCS2抗體 Rabbit Polyclonal SPCS2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4595 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

WB Predicted band size25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human SPCS2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: K-562 cell, Human placenta tissue, Mouse adrenal gland tissue, HT-29 cell, NIH/3T3 cell, Rat lung tissue, Primary antibody: P09113(SPCS2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09113(SPCS2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09113(SPCS2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于SPCS2抗體的3篇參考文獻示例(注:以下內(nèi)容為假設(shè)性示例,實際文獻需通過學術(shù)數(shù)據(jù)庫檢索確認):

1. **文獻名稱**:*SPCS2 regulates the secretory pathway by interacting with COPII subunits*

**作者**:Saito K. et al.

**摘要**:研究利用SPCS2抗體通過免疫印跡和免疫組化技術(shù),揭示了SPCS2蛋白在COPII囊泡形成中的作用,證實其通過調(diào)控內(nèi)質(zhì)網(wǎng)-高爾基體運輸影響分泌蛋白的成熟。

2. **文獻名稱**:*A monoclonal antibody-based assay for quantifying SPCS2 in mammalian cells*

**作者**:Chen L., Zhou Y.

**摘要**:開發(fā)了一種高特異性SPCS2單克隆抗體,并建立定量檢測方法,驗證了SPCS2在不同細胞系中的表達差異及其與內(nèi)質(zhì)網(wǎng)應(yīng)激的相關(guān)性。

3. **文獻名稱**:*SPCS2 depletion disrupts hepatitis C virus replication via impaired signal peptide cleavage*

**作者**:Li J. et al.

**摘要**:通過SPCS2抗體進行蛋白質(zhì)功能抑制實驗,證明SPCS2是丙肝病毒顆粒組裝的關(guān)鍵宿主因子,其缺失導致病毒多蛋白前體加工缺陷,顯著抑制病毒復制。

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建議通過PubMed或Google Scholar以關(guān)鍵詞“SPCS2 antibody”或“SPCS2 function”檢索最新文獻以獲取真實參考文獻。

       

背景信息

SPCS2 (Signal Peptidase Complex Subunit 2) is a key component of the endoplasmic reticulum (ER)-resident signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal peptides from nascent secretory and membrane proteins during their translocation into the ER. As part of the SPC, SPCS2 plays a critical role in protein maturation, trafficking, and quality control. Dysregulation of SPCS2 has been implicated in various diseases, including viral infections (e.g., flaviviruses exploit the SPC for viral polyprotein processing) and neurodegenerative disorders linked to ER stress.

Antibodies targeting SPCS2 are essential tools for studying its expression, localization, and function in cellular models. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate SPC assembly, ER-associated degradation (ERAD), and cellular responses to secretory pathway stress. SPCS2-specific antibodies also aid in exploring its interaction with viral proteins or disease-associated mutants.

Recent studies highlight SPCS2's potential as a therapeutic target, particularly in antiviral strategies or conditions involving proteostasis imbalance. Validated SPCS2 antibodies (e.g., from commercial sources like Abcam or Sigma-Aldrich) often undergo rigorous specificity testing, including knockout cell line validation, ensuring reliability in both basic research and translational applications.

       
關(guān)鍵字: SPCS2抗體;SPCS2;SPCS2 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

SPCS2抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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