中文名稱:SPCS2抗體 | 英文名稱:Rabbit Polyclonal SPCS2 Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 4595 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無 | 靶點(diǎn): SPCS2 |
WB | 咨詢技術(shù) | Human,Mouse,Rat |
IF | 咨詢技術(shù) | Human,Mouse,Rat |
IHC | 1/30-1/150 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
WB Predicted band size | 25 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human SPCS2 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: K-562 cell, Human placenta tissue, Mouse adrenal gland tissue, HT-29 cell, NIH/3T3 cell, Rat lung tissue, Primary antibody: P09113(SPCS2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09113(SPCS2 Antibody) at dilution 1/40. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09113(SPCS2 Antibody) at dilution 1/40. (Original magnification: ×200)
以下是關(guān)于SPCS2抗體的3篇參考文獻(xiàn)示例(注:以下內(nèi)容為假設(shè)性示例,實(shí)際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫檢索確認(rèn)):
1. **文獻(xiàn)名稱**:*SPCS2 regulates the secretory pathway by interacting with COPII subunits*
**作者**:Saito K. et al.
**摘要**:研究利用SPCS2抗體通過免疫印跡和免疫組化技術(shù),揭示了SPCS2蛋白在COPII囊泡形成中的作用,證實(shí)其通過調(diào)控內(nèi)質(zhì)網(wǎng)-高爾基體運(yùn)輸影響分泌蛋白的成熟。
2. **文獻(xiàn)名稱**:*A monoclonal antibody-based assay for quantifying SPCS2 in mammalian cells*
**作者**:Chen L., Zhou Y.
**摘要**:開發(fā)了一種高特異性SPCS2單克隆抗體,并建立定量檢測方法,驗(yàn)證了SPCS2在不同細(xì)胞系中的表達(dá)差異及其與內(nèi)質(zhì)網(wǎng)應(yīng)激的相關(guān)性。
3. **文獻(xiàn)名稱**:*SPCS2 depletion disrupts hepatitis C virus replication via impaired signal peptide cleavage*
**作者**:Li J. et al.
**摘要**:通過SPCS2抗體進(jìn)行蛋白質(zhì)功能抑制實(shí)驗(yàn),證明SPCS2是丙肝病毒顆粒組裝的關(guān)鍵宿主因子,其缺失導(dǎo)致病毒多蛋白前體加工缺陷,顯著抑制病毒復(fù)制。
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建議通過PubMed或Google Scholar以關(guān)鍵詞“SPCS2 antibody”或“SPCS2 function”檢索最新文獻(xiàn)以獲取真實(shí)參考文獻(xiàn)。
SPCS2 (Signal Peptidase Complex Subunit 2) is a key component of the endoplasmic reticulum (ER)-resident signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal peptides from nascent secretory and membrane proteins during their translocation into the ER. As part of the SPC, SPCS2 plays a critical role in protein maturation, trafficking, and quality control. Dysregulation of SPCS2 has been implicated in various diseases, including viral infections (e.g., flaviviruses exploit the SPC for viral polyprotein processing) and neurodegenerative disorders linked to ER stress.
Antibodies targeting SPCS2 are essential tools for studying its expression, localization, and function in cellular models. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate SPC assembly, ER-associated degradation (ERAD), and cellular responses to secretory pathway stress. SPCS2-specific antibodies also aid in exploring its interaction with viral proteins or disease-associated mutants.
Recent studies highlight SPCS2's potential as a therapeutic target, particularly in antiviral strategies or conditions involving proteostasis imbalance. Validated SPCS2 antibodies (e.g., from commercial sources like Abcam or Sigma-Aldrich) often undergo rigorous specificity testing, including knockout cell line validation, ensuring reliability in both basic research and translational applications.
成立日期 | 2024-07-02 (2年) | 注冊資本 | 20萬人民幣 |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
主營行業(yè) | 抗體,蛋白組學(xué),細(xì)胞生物學(xué) | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
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詢價(jià) |
VIP3年
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2025-08-01 | |
¥1800 |
VIP1年
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2025-07-28 | |
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上海華盈生物醫(yī)藥科技有限公司
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2025-08-02 | ||
¥1280 |
湖北艾普蒂生物工程有限公司
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2025-06-04 |