The ZNF486 antibody is a research tool designed to target the zinc finger protein 486 (ZNF486), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF486 is implicated in transcriptional regulation, potentially through chromatin remodeling or DNA-binding interactions, given its structural features: multiple C2H2 zinc finger motifs and a KRAB domain known to recruit epigenetic modifiers. While its precise biological role remains under investigation, ZNF486 is thought to influence gene expression networks involved in cellular differentiation, development, and possibly oncogenesis. Aberrant expression of ZNF486 has been observed in certain cancers, suggesting a potential role in tumorigenesis or tumor suppression.
The ZNF486 antibody is typically developed in animal hosts (e.g., rabbit or mouse) as a polyclonal or monoclonal antibody, validated for applications like Western blotting, immunohistochemistry, or immunofluorescence. Researchers use it to study ZNF486's expression patterns, subcellular localization, and interactions with other proteins or nucleic acids. Its utility extends to exploring ZNF486's involvement in diseases, such as hematologic malignancies or solid tumors, where dysregulation of zinc finger proteins is common. However, detailed functional studies and standardized validation protocols for this antibody are still evolving, reflecting the ongoing exploration of ZNF486's role in cellular and disease contexts.