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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08991(WDR45 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08991(WDR45 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

WDR45 (WD repeat domain 45), also known as WIPI4. is a gene located on the X chromosome that encodes a β-propeller scaffold protein involved in autophagosome formation. It belongs to the WIPI (WD40 repeat proteins interacting with phosphoinositides) family, which regulates autophagy by recruiting other proteins to phagophore membranes. Mutations in WDR45 are linked to neurodegenerative disorders, particularly β-propeller protein-associated neurodegeneration (BPAN), a subtype of neurodegeneration with brain iron accumulation (NBIA). BPAN is characterized by iron deposition in the basal ganglia, developmental delays, and progressive motor and cognitive impairments.

WDR45 antibodies are essential tools for studying the protein's expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate WDR45 levels in patient-derived cells, animal models, or autophagy-related studies. These antibodies help identify pathogenic mutations, assess autophagic flux disruptions, and explore mechanisms underlying iron metabolism dysregulation in BPAN. Commercially available WDR45 antibodies are typically developed using recombinant protein fragments or synthetic peptides, with validation in knockout models to confirm specificity. Reliable detection of WDR45 is critical for advancing research on autophagy-related pathways and developing therapeutic strategies for NBIA disorders.