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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08924(NME8 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

NME8 (non-metastatic cells 8. also known as TXNDC3) is a gene encoding a protein involved in cellular processes related to ciliary function and motility. It belongs to the NME/NM23 family, though its role differs from the well-characterized tumor metastasis suppressor functions of other family members. The NME8 protein is predominantly expressed in tissues with motile cilia, such as the respiratory tract and sperm flagella, and is critical for proper ciliary structure and movement. It interacts with components of the dynein regulatory complex (DRC) in cilia, aiding in microtubule sliding and coordinated ciliary beating. Dysregulation of NME8 has been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory infections and infertility due to impaired ciliary motility.

Antibodies targeting NME8 are essential tools for studying its expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate ciliary biology and diagnose ciliopathies. Commercially available NME8 antibodies are typically raised against specific epitopes, such as the N-terminal or thioredoxin-like domains, and require validation for specificity given potential cross-reactivity with other thioredoxin family proteins. Recent studies also explore NME8's potential roles beyond cilia, including associations with cancer progression and neurodegenerative diseases, underscoring the antibody's utility in diverse research areas.