TPT1抗體—艾普蒂

價(jià)格	詢(xún)價(jià)
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	上海
更新日期	2025-05-19

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產(chǎn)品詳情

中文名稱(chēng):TPT1抗體	英文名稱(chēng):Rabbit Polyclonal TPT1 Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4400 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類(lèi)別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Rabbit
偶聯(lián)物: 無(wú)	靶點(diǎn): TPT1

驗(yàn)證與應(yīng)用

應(yīng)用及物種

WB	1/1000-1/5000	Human,Mouse,Rat
IF	咨詢(xún)技術(shù)	Human,Mouse,Rat
IHC	1/45-1/300	Human,Mouse,Rat
ICC	技術(shù)咨詢(xún)	Human,Mouse,Rat
FCM	咨詢(xún)技術(shù)	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

產(chǎn)品詳情

Aliases	HRF; p02; p23; TCTP
WB Predicted band size	20 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Full length fusion protein
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P08847(TPT1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08847(TPT1 Antibody) at dilution 1/85. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P08847(TPT1 Antibody) at dilution 1/85. (Original magnification: ×200)

參考文獻(xiàn)

以下是關(guān)于TPT1(TCTP)抗體的3篇參考文獻(xiàn)的簡(jiǎn)要信息：

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1. **文獻(xiàn)名稱(chēng)**: *TCTP as a therapeutic target in cancer*

**作者**: Amson, R., et al.

**摘要**: 該研究探討了TCTP(TPT1)在腫瘤發(fā)生中的作用，并利用特異性抗體驗(yàn)證其在乳腺癌細(xì)胞中的高表達(dá)。研究提出TCTP抗體可用于靶向治療，通過(guò)抑制TCTP功能誘導(dǎo)腫瘤細(xì)胞凋亡。

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2. **文獻(xiàn)名稱(chēng)**: *Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase α subunit and inhibits the pump activity*

**作者**: Jung, J., et al.

**摘要**: 研究通過(guò)免疫共沉淀(使用TPT1抗體)揭示TCTP與Na,K-ATPase的相互作用，并證明其通過(guò)調(diào)控離子泵活性影響細(xì)胞應(yīng)激反應(yīng)，為癌癥治療的分子機(jī)制提供新見(jiàn)解。

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3. **文獻(xiàn)名稱(chēng)**: *TCTP overexpression as a prognostic marker in hepatocellular carcinoma*

**作者**: Chan, T.H., et al.

**摘要**: 利用TPT1抗體對(duì)肝癌組織進(jìn)行免疫組化分析，發(fā)現(xiàn)TCTP高表達(dá)與患者不良預(yù)后顯著相關(guān)，提示其可作為肝癌診斷和預(yù)后的生物標(biāo)志物。

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**備注**: TPT1(TCTP)抗體相關(guān)研究多集中在癌癥機(jī)制、治療靶點(diǎn)及診斷標(biāo)記物領(lǐng)域。如需具體文獻(xiàn)鏈接或擴(kuò)展內(nèi)容，可進(jìn)一步提供研究方向或數(shù)據(jù)庫(kù)篩選條件。

背景信息

The TPT1 (Tumor Protein Translationally-Controlled 1) antibody is a tool used to study the TPT1 protein, a highly conserved, multifunctional molecule encoded by the *TPT1* gene. Originally identified as a translationally controlled tumor protein, TPT1 (also called TCTP) is ubiquitously expressed across eukaryotes and plays roles in cell cycle regulation, apoptosis, calcium homeostasis, and stress response. Structurally, it is a small cytoplasmic protein (~19-21 kDa) with a flexible conformation, enabling interactions with diverse binding partners like microtubules, Bcl-2 family proteins, and mTOR pathway components.

TPT1 is implicated in cancer progression, as its overexpression correlates with tumor growth, metastasis, and therapy resistance. It regulates pathways such as mTOR signaling (promoting cell proliferation) and p53 stabilization (modulating apoptosis). Additionally, TPT1 participates in immune responses and developmental processes. Antibodies targeting TPT1 are widely used in research to detect its expression levels via Western blot, immunohistochemistry, or immunofluorescence, aiding studies on cancer biology, neurodegeneration, and autophagy. Some commercial TPT1 antibodies are raised in rabbits or mice using recombinant protein antigens or synthetic peptides. Validation includes specificity checks using knockout cell lines or siRNA-mediated knockdown. Beyond research, TPT1 antibodies have potential diagnostic applications, as elevated TPT1 levels in serum or tissues may serve as biomarkers for certain cancers or inflammatory diseases.

關(guān)鍵字： TPT1抗體;TPT1;TPT1 Antibody;

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