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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08779(SLITRK5 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

SLITRK5 (SLIT and NTRK-like family member 5) is a neuronal transmembrane protein belonging to the SLITRK family, which plays critical roles in synapse formation, neural circuit development, and synaptic plasticity. Primarily expressed in the central nervous system, SLITRK5 localizes to inhibitory synapses and interacts with postsynaptic proteins like PTPδ to regulate synaptic signaling. Its dysfunction has been implicated in neuropsychiatric disorders, particularly obsessive-compulsive disorder (OCD) and Tourette syndrome. Studies in Slitrk5-deficient mice revealed compulsive grooming behaviors and corticostriatal abnormalities, modeling OCD-like phenotypes, highlighting its potential role in pathological anxiety and repetitive behaviors.

Antibodies targeting SLITRK5 are essential tools for investigating its expression, localization, and function in neural tissues. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to map SLITRK5 distribution in brain regions like the striatum and cortex. Such research aids in understanding how SLITRK5 modulates synaptic balance and contributes to disease mechanisms. Additionally, these antibodies are used to validate SLITRK5 knockdown/knockout models and assess protein interactions. While therapeutic applications remain exploratory, SLITRK5 antibodies hold promise for elucidating pathways in neurodevelopmental disorders and identifying biomarkers or targets for intervention. Ongoing research continues to uncover its precise molecular roles and therapeutic potential.