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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08745(SDF4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08745(SDF4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of SDF4 Antibody**

SDF4 (Stromal Cell-Derived Factor 4), also known as Ca2?-binding protein 45 (Cab45), is a soluble protein primarily localized in the Golgi apparatus. It belongs to the CREC family of calcium-binding proteins and plays a critical role in regulating intracellular calcium-dependent processes, including protein sorting, secretion, and post-translational modifications. SDF4 is particularly implicated in the trafficking of secretory cargoes, such as growth factors and extracellular matrix components, by facilitating their packaging into vesicles.

Antibodies targeting SDF4 are valuable tools for studying its expression, localization, and functional interactions in cellular and tissue contexts. Research has linked SDF4 dysregulation to pathologies like cancer, cardiovascular diseases, and metabolic disorders, where altered secretory pathways contribute to disease progression. For instance, elevated SDF4 levels have been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target.

SDF4 antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate its role in Golgi function, calcium signaling, and disease mechanisms. Recent studies also explore its involvement in autophagy and apoptosis, expanding its relevance in cellular homeostasis. As research advances, SDF4 antibodies continue to support mechanistic insights into secretory pathway dysfunctions and their clinical implications.