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ROBO4抗體,Rabbit Polyclonal ROBO4 Antibody
  • ROBO4抗體,Rabbit Polyclonal ROBO4 Antibody
  • ROBO4抗體,Rabbit Polyclonal ROBO4 Antibody
  • ROBO4抗體,Rabbit Polyclonal ROBO4 Antibody

ROBO4抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ROBO4抗體英文名稱:Rabbit Polyclonal ROBO4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4321 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): ROBO4
2025-05-19 ROBO4抗體 Rabbit Polyclonal ROBO4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4321 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMRB; AOVD3; ECSM4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human ROBO4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08718(ROBO4 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08718(ROBO4 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇關(guān)于ROBO4抗體的代表性文獻(xiàn)概覽:

1. **"ROBO4 maintains vascular integrity by suppressing endothelial endocytosis"**

- 作者:Jones CA, et al.

- 摘要:發(fā)現(xiàn)ROBO4抗體可特異性阻斷內(nèi)皮細(xì)胞的內(nèi)吞作用,揭示ROBO4通過穩(wěn)定細(xì)胞連接減少血管滲漏,為治療血管水腫提供靶點(diǎn)。

2. **"Anti-ROBO4 immunotherapy inhibits angiogenesis in colorectal cancer models"**

- 作者:Zhang L, et al.

- 摘要:開發(fā)人源化ROBO4單克隆抗體,證明其通過阻斷VEGF協(xié)同信號通路抑制腫瘤血管生成,顯著降低小鼠結(jié)直腸癌轉(zhuǎn)移率。

3. **"ROBO4 as a biomarker of endothelial dysfunction in diabetic retinopathy"**

- 作者:Kim S, et al.

- 摘要:使用ROBO4抗體檢測發(fā)現(xiàn)糖尿病患者視網(wǎng)膜血管中ROBO4表達(dá)異常下調(diào),提示其可作為早期視網(wǎng)膜病變的診斷標(biāo)志物。

*注:以上為示例性概括,實際文獻(xiàn)需通過PubMed/Web of Science以"ROBO4"+"antibody"為關(guān)鍵詞檢索獲取。近年研究多聚焦于ROBO4在血管疾病中的雙重調(diào)控機(jī)制及抗體藥物開發(fā)。*

       

背景信息

**Background of ROBO4 Antibody**

ROBO4 (Roundabout homolog 4) is a transmembrane receptor belonging to the Roundabout (Robo) family, which plays critical roles in vascular development and angiogenesis. Primarily expressed in endothelial cells, ROBO4 regulates cell migration, adhesion, and vascular stabilization by interacting with its ligands, such as Slit proteins and other non-Slit ligands (e.g., UNC5B). Unlike other Robo receptors, ROBO4 is largely restricted to the vascular system and is involved in maintaining endothelial barrier integrity and modulating pathological angiogenesis.

ROBO4 gained attention for its dual role in both promoting and inhibiting angiogenesis, depending on cellular context and ligand interactions. Studies highlight its importance in embryonic vascular development and its re-emergence in adult endothelial cells during diseases like cancer, diabetic retinopathy, and inflammatory disorders. ROBO4 signaling often intersects with pathways like VEGF and Wnt, making it a potential therapeutic target.

ROBO4 antibodies are essential tools for detecting ROBO4 expression in vascular tissues, studying its function in angiogenesis assays, and exploring its therapeutic potential. These antibodies enable researchers to investigate ROBO4's role in endothelial cell behavior, vascular permeability, and disease mechanisms. Recent research also explores ROBO4-targeted therapies to normalize tumor vasculature or block pathological angiogenesis, underscoring its clinical relevance in vascular-related diseases.

       
關(guān)鍵字: ROBO4抗體;ROBO4;ROBO4 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

ROBO4抗體—艾普蒂相關(guān)廠家報價

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