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RBM5抗體,Rabbit Polyclonal RBM5 Antibody
  • RBM5抗體,Rabbit Polyclonal RBM5 Antibody
  • RBM5抗體,Rabbit Polyclonal RBM5 Antibody
  • RBM5抗體,Rabbit Polyclonal RBM5 Antibody

RBM5抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:RBM5抗體英文名稱:Rabbit Polyclonal RBM5 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4298 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: RBM5
2025-05-19 RBM5抗體 Rabbit Polyclonal RBM5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4298 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesG15; H37; RMB5; LUCA15
WB Predicted band size92 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human RBM5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-6: 823 cells, A549 cells, K562 cells, 293T cells, hepg2 cells, huvec cells, Primary antibody: P08682(RBM5 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08682(RBM5 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08682(RBM5 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是關于RBM5抗體的模擬參考文獻示例(僅供學術參考,非真實文獻):

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1. **文獻名稱**: *RBM5 Expression in Lung Cancer: Prognostic Implications and Antibody Validation*

**作者**: Sutherland LC, et al.

**摘要**: 本研究通過免疫組化(IHC)和Western blot驗證了RBM5抗體在肺癌組織中的特異性,發(fā)現(xiàn)RBM5低表達與患者預后不良相關,提示其作為潛在生物標志物的價值。

2. **文獻名稱**: *RBM5 Regulates Apoptosis via Interaction with Bcl-xL: Insights from Antibody-Based Functional Assays*

**作者**: Rintala-Maki ND, et al.

**摘要**: 利用RBM5特異性抗體進行免疫共沉淀(Co-IP)和流式細胞術分析,揭示RBM5通過結合Bcl-xL調(diào)控細胞凋亡,為癌癥治療靶點研究提供依據(jù)。

3. **文獻名稱**: *Epigenetic Silencing of RBM5 in Breast Cancer: Validation by qRT-PCR and Immunohistochemistry*

**作者**: Oh JJ, et al.

**摘要**: 通過qRT-PCR和RBM5抗體驅動的免疫組化分析,證實乳腺癌中RBM5的表觀遺傳沉默,其表達缺失與腫瘤侵襲性增強相關。

4. **文獻名稱**: *RBM5 as a Tumor Suppressor: Antibody Development and Clinical Correlation in Colorectal Cancer*

**作者**: Edamatsu H, et al.

**摘要**: 開發(fā)了一種高特異性RBM5單克隆抗體,并應用于結直腸癌組織微陣列分析,證明RBM5表達降低與腫瘤分期進展及轉移風險增加顯著相關。

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**注意**:以上文獻為示例性質,實際研究需通過PubMed、Web of Science等平臺檢索真實文獻(關鍵詞:RBM5 antibody, immunohistochemistry, cancer)。

       

背景信息

The RNA-binding motif protein 5 (RBM5) is a member of the RNA-binding protein family, known for its role in post-transcriptional gene regulation, particularly in mRNA splicing, stability, and translation. RBM5 contains conserved RNA recognition motifs (RRMs) and a zinc finger domain, enabling interactions with RNA and protein partners. It is implicated in critical cellular processes, including cell cycle control, apoptosis, and differentiation. Research highlights its tumor-suppressive functions, as RBM5 expression is frequently downregulated in cancers such as lung, breast, and prostate cancer. It modulates alternative splicing of apoptosis-related genes (e.g., Bcl-x, FAS) and regulates signaling pathways like the p53 and MAPK cascades, influencing cancer progression and therapy resistance.

RBM5 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate RBM5's role in normal physiology and disease. Commercially available antibodies target specific epitopes within its N-terminal or C-terminal regions, with validation across human and model organism tissues. Dysregulation of RBM5 has also been linked to neurological disorders, expanding its research relevance. However, challenges remain in understanding its isoform-specific functions and regulatory networks. Ongoing studies aim to clarify RBM5's potential as a diagnostic biomarker or therapeutic target, particularly in precision oncology.

       
關鍵字: RBM5抗體;RBM5;RBM5 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

RBM5抗體—艾普蒂相關廠家報價

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