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RASA1抗體,Rabbit Polyclonal RASA1 Antibody
  • RASA1抗體,Rabbit Polyclonal RASA1 Antibody
  • RASA1抗體,Rabbit Polyclonal RASA1 Antibody
  • RASA1抗體,Rabbit Polyclonal RASA1 Antibody

RASA1抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:RASA1抗體英文名稱:Rabbit Polyclonal RASA1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4291 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: RASA1
2025-05-19 RASA1抗體 Rabbit Polyclonal RASA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4291 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGAP; PKWS; RASA; CMAVM; CM-AVM; RASGAP; p120GAP; p120RASGAP
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenFusion protein of human RASA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08671(RASA1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08671(RASA1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于RASA1抗體的參考文獻示例(注:以下文獻信息為示例性內(nèi)容,非真實存在的論文):

1. **文獻名稱**: "RASA1-Specific Monoclonal Antibody Development and Application in Vascular Malformation Studies"

**作者**: Smith A, et al.

**摘要**: 本研究開發(fā)了一種針對RASA1蛋白的高特異性單克隆抗體,并通過Western blot和免疫組織化學(xué)驗證其在人和小鼠組織中的適用性。研究利用該抗體揭示了RASA1在遺傳性血管畸形患者組織中的表達缺失,支持其在調(diào)節(jié)內(nèi)皮細胞RAS信號通路中的關(guān)鍵作用。

2. **文獻名稱**: "RASA1 Antibody-Based Detection of Protein Localization in Developmental Angiogenesis"

**作者**: Chen L, et al.

**摘要**: 通過免疫熒光和共聚焦顯微鏡技術(shù),使用RASA1多克隆抗體分析了小鼠胚胎血管系統(tǒng)的蛋白分布。研究發(fā)現(xiàn)RASA1在血管內(nèi)皮細胞中高表達,且其空間定位與VEGF信號通路活性相關(guān),提示其通過調(diào)控RAS-MAPK通路抑制過度血管生成。

3. **文獻名稱**: "Functional Characterization of RASA1 Antibody in Neurofibromatosis Type 1 Models"

**作者**: Gupta R, et al.

**摘要**: 本研究利用商業(yè)化RASA1抗體探究了神經(jīng)纖維瘤病1型(NF1)模型中RASA1與神經(jīng)纖維蛋白的相互作用??贵w通過免疫沉淀證實了RASA1在NF1缺失細胞中的異常聚集,為靶向RAS信號的治療策略提供了實驗依據(jù)。

4. **文獻名稱**: "RASA1 Expression Profiling in Cancer: Validation of a Novel Antibody for Clinical Biomarker Studies"

**作者**: Kim H, et al.

**摘要**: 驗證了一種新型兔源RASA1抗體在結(jié)直腸癌組織芯片中的可靠性,發(fā)現(xiàn)RASA1低表達與腫瘤侵襲性和KRAS突變顯著相關(guān)。該抗體被推薦為潛在預(yù)后標志物檢測工具。

(注:實際文獻需通過PubMed、Google Scholar等平臺以“RASA1 antibody”或“RASA1 immunodetection”為關(guān)鍵詞檢索獲取。)

       

背景信息

The RASA1 antibody is designed to detect RAS p21 protein activator 1 (RASA1), a critical regulatory protein involved in the RAS/MAPK signaling pathway. RASA1. also known as p120-RasGAP, functions as a GTPase-activating protein (GAP) that negatively regulates RAS activity by accelerating its intrinsic GTPase activity, thereby converting active GTP-bound RAS to its inactive GDP-bound form. This regulation is essential for controlling cellular processes such as proliferation, differentiation, and apoptosis. Mutations or dysregulation of RASA1 are linked to vascular malformations, including capillary malformation-arteriovenous malformation (CM-AVM) syndrome, and have been implicated in certain cancers due to aberrant RAS signaling.

RASA1 antibodies are widely used in research to study protein expression, localization, and function in various tissues and disease models. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These tools help elucidate RASA1's role in vascular development, tumor suppression, and signal transduction mechanisms. Additionally, RASA1 antibodies contribute to diagnostic investigations of genetic disorders and potential therapeutic strategies targeting RAS pathway dysregulation. Their specificity and reliability make them vital for advancing understanding of RASA1-related pathologies and cellular signaling networks.

       
關(guān)鍵字: RASA1抗體;RASA1;RASA1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

RASA1抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
武漢佰樂博生物技術(shù)有限公司
2025-08-08
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥2580
VIP6年
上海澤葉生物科技有限公司
2025-08-08
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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