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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-5: K562 cells, hepg2 cells, 231 cells, Jurkat cells, Raji cells, Primary antibody: P08656(PTRH2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08656(PTRH2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08656(PTRH2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The PTRH2 (Peptidyl-tRNA Hydrolase 2) antibody is a tool used to detect the PTRH2 protein, encoded by the *PTRH2* gene, which plays critical roles in mitochondrial function, cell proliferation, and apoptosis. PTRH2 is a conserved enzyme involved in hydrolyzing peptidyl-tRNA molecules, essential for recycling stalled translational complexes and maintaining protein synthesis fidelity. Mutations in *PTRH2* are linked to Perrault syndrome, a rare autosomal recessive disorder characterized by sensorineural hearing loss and ovarian dysfunction, underscoring its importance in neurological and reproductive health.

PTRH2 antibodies are widely utilized in research to investigate the protein's expression, localization, and interaction partners. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study PTRH2's distribution in tissues, particularly in mitochondria-rich cells. Studies using these antibodies have revealed PTRH2's involvement in stress responses, tumor suppression, and neurodegenerative pathways. Commercially available antibodies are often validated for specificity via knockout controls or siRNA silencing. Researchers rely on these reagents to explore PTRH2's mechanistic roles in diseases, including cancer, mitochondrial disorders, and Perrault syndrome, aiming to develop targeted therapies or diagnostic markers. Proper validation remains crucial to avoid cross-reactivity with homologous proteins.