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PEF1抗體,Rabbit Polyclonal PEF1 Antibody
  • PEF1抗體,Rabbit Polyclonal PEF1 Antibody
  • PEF1抗體,Rabbit Polyclonal PEF1 Antibody
  • PEF1抗體,Rabbit Polyclonal PEF1 Antibody

PEF1抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PEF1抗體英文名稱:Rabbit Polyclonal PEF1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4257 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): PEF1
2025-05-19 PEF1抗體 Rabbit Polyclonal PEF1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4257 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesABP32; PEF1A
WB Predicted band size30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PEF1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, hela cells, 293T cells, human thyroid cancer tissue, Primary antibody: P08612(PEF1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08612(PEF1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08612(PEF1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于PEF1抗體的示例參考文獻(xiàn)(**注:以下為模擬示例,非真實(shí)存在的文獻(xiàn)**):

1. **"PEF1 regulates cell cycle progression via calcium signaling in mammalian cells"**

*Authors: Smith A, et al.*

摘要:本研究通過PEF1抗體檢測(cè)發(fā)現(xiàn),PEF1蛋白通過調(diào)控細(xì)胞內(nèi)鈣離子濃度影響G1/S期轉(zhuǎn)換,揭示其在細(xì)胞周期中的關(guān)鍵作用。

2. **"Development and validation of a specific PEF1 monoclonal antibody for immunohistochemical analysis"**

*Authors: Tanaka K, et al.*

摘要:團(tuán)隊(duì)開發(fā)了一種高特異性PEF1單克隆抗體,驗(yàn)證其在人類組織樣本中的可靠性,并應(yīng)用于癌癥組織中PEF1蛋白表達(dá)異常的檢測(cè)。

3. **"PEF1 interacts with apoptotic regulators: Insights from co-immunoprecipitation assays"**

*Authors: Lee J, et al.*

摘要:利用PEF1抗體進(jìn)行免疫共沉淀實(shí)驗(yàn),發(fā)現(xiàn)PEF1與Bcl-2家族蛋白相互作用,提示其在凋亡通路中的潛在調(diào)控機(jī)制。

4. **"PEF1 as a biomarker in neurodegenerative disorders: Evidence from Western blot analysis"**

*Authors: Müller R, et al.*

摘要:通過Western blot結(jié)合PEF1抗體,研究發(fā)現(xiàn)阿爾茨海默病患者腦脊液中PEF1表達(dá)顯著降低,提示其作為疾病生物標(biāo)志物的可能性。

**提示**:實(shí)際研究中建議通過PubMed或Google Scholar檢索最新文獻(xiàn),關(guān)鍵詞如“PEF1 antibody”或“PEF1 function”。

       

背景信息

The PEF1 antibody targets the Partner of Epidermal Growth Factor Receptor Substrate 15 (PEF1), a protein implicated in cellular adhesion, signaling, and intracellular trafficking. PEF1. also known as PTPRF-interacting protein (PTPRFIP1), belongs to the PEF protein family and contains conserved SH3 and phosphotyrosine-binding (PTB) domains. It interacts with cytoskeletal components and signaling molecules, including Eps15 and epidermal growth factor receptor (EGFR), modulating pathways critical for cell proliferation, migration, and polarity. Research highlights its role in neurodevelopment, as PEF1 mutations are linked to intellectual disability and autism spectrum disorders, likely due to disrupted synaptic function and neuronal connectivity.

In cancer biology, PEF1 is overexpressed in certain malignancies, influencing tumor progression via EGFR or integrin-mediated pathways. The PEF1 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization (e.g., endosomes, Golgi), and interactions. Recent studies employ it to explore PEF1's involvement in vesicular transport, cell-matrix adhesion, and epithelial-mesenchymal transition (EMT). Its utility extends to disease models, aiding in deciphering PEF1's dual roles as a tumor suppressor or promoter, depending on cellular context. This antibody remains a key tool for unraveling PEF1's complex regulatory networks in health and disease.

       
關(guān)鍵字: PEF1抗體;PEF1;PEF1 Antibody;

公司簡(jiǎn)介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

PEF1抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥990
VIP6年
上海澤葉生物科技有限公司
2025-08-01
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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