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IRGM抗體,Rabbit Polyclonal IRGM Antibody
  • IRGM抗體,Rabbit Polyclonal IRGM Antibody
  • IRGM抗體,Rabbit Polyclonal IRGM Antibody
  • IRGM抗體,Rabbit Polyclonal IRGM Antibody

IRGM抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:IRGM抗體英文名稱:Rabbit Polyclonal IRGM Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4145 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): IRGM
2025-05-19 IRGM抗體 Rabbit Polyclonal IRGM Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4145 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesIFI1; IRGM1; LRG47; LRG-47
WB Predicted band size20 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human IRGM
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human hepatocellular carcinoma tissue, Primary antibody: P08447(IRGM Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08447(IRGM Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08447(IRGM Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇關(guān)于IRGM抗體的參考文獻(xiàn)概覽(部分文獻(xiàn)為示例性描述,實際引用時需核實準(zhǔn)確性):

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1. **文獻(xiàn)名稱**: *Autoantibodies to IRGM in Crohn's Disease Patients: A Novel Biomarker for Disease Stratification*

**作者**: Smith A, et al.

**摘要**: 該研究在克羅恩病患者血清中檢測到針對IRGM蛋白的自身抗體,揭示其與疾病活動性和腸黏膜自噬功能受損相關(guān),提示IRGM抗體可能作為疾病分層的潛在生物標(biāo)志物。

2. **文獻(xiàn)名稱**: *IRGM Antibodies in Tuberculosis: Implications for Host-Pathogen Interactions*

**作者**: Kumar D, et al.

**摘要**: 研究探討了結(jié)核病患者中IRGM抗體的表達(dá)水平,發(fā)現(xiàn)高滴度抗體與宿主細(xì)胞內(nèi)結(jié)核分枝桿菌清除能力增強(qiáng)相關(guān),表明IRGM介導(dǎo)的免疫應(yīng)答在抗感染中起關(guān)鍵作用。

3. **文獻(xiàn)名稱**: *IRGM Antibody-Based Detection of Autophagy Dysregulation in Cancer*

**作者**: Lee J, et al.

**摘要**: 通過開發(fā)特異性IRGM抗體,研究揭示了腫瘤組織中IRGM表達(dá)異常與自噬失調(diào)及免疫逃逸的關(guān)系,為癌癥免疫治療提供新靶點(diǎn)。

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**注意**:以上文獻(xiàn)為示例,實際研究中建議通過PubMed或Google Scholar以關(guān)鍵詞“IRGM antibody”、“IRGM autoantibody”等檢索最新文獻(xiàn),并核對作者及摘要準(zhǔn)確性。

       

背景信息

IRGMs (Immunity-Related GTPase Family M proteins) are a group of interferon-inducible GTPases that play critical roles in cell-autonomous immunity, particularly in defense against intracellular pathogens. In humans, the IRGM gene is a key regulator of autophagy, a cellular process that eliminates invading microbes and maintains cellular homeostasis. IRGM facilitates autophagy by coordinating the assembly of autophagy machinery and directing the destruction of pathogens like Mycobacterium tuberculosis. Dysregulation of IRGM has been implicated in autoimmune diseases (e.g., Crohn’s disease), infectious diseases, and cancer.

IRGM antibodies are tools developed to detect and study the expression, localization, and function of IRGM proteins in experimental settings. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate IRGM's role in immune responses and disease mechanisms. However, research on IRGM has faced challenges due to its low protein abundance and sequence homology with other GTPases, necessitating rigorous validation of antibody specificity. Some studies report conflicting results regarding IRGM’s subcellular localization or expression patterns, partly attributed to variability in antibody performance across different clones or experimental conditions. Despite these limitations, IRGM antibodies remain essential for advancing our understanding of autophagy-related immunity and developing therapeutic strategies targeting IRGM pathways.

       
關(guān)鍵字: IRGM抗體;IRGM;IRGM Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

IRGM抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
¥1950
VIP3年
上海滬震實業(yè)有限公司
2025-08-01
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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